in the inoculated Vaccine Difeafe. 315 
eruptions refembled the fmall-pox: nor do I reckon among 
the eruptive cafes thofe in which, now and then, a rafh broke 
out about the 14th day after inoculation; and which was as 
troublefome as the Urticaria. My experience, then, with re- 
fpeé&t to the cafes of eruptions being diminifhed in number 
_ by avoiding inoculation with matter of fimilar eruptive cafes, 
coincides with Dr. Woodville’s; and confirms what he has 
already fo ufefully communicated to the public. It was ob- 
vious to fufpect, on the firft occurrence of the eruptive cafes, 
that variolous matter, in an unobferved way, but from fources 
which could not even be conjectured, had been introduced 
into the conftitution inftead of the vaccine poifon. This 
conjecture, in fpite of the cleareft evidence of fenfe refpect- 
ing the nature of the matter ufed, received fome countenance 
from the non-appearance of eruptions as above ftated; but, 
from the occurrence of fuch cafes, in the practice of other 
Inoculators, in the laft autumn and this winter, I think it 
is very unreafonable to doubt any longer, that, either on 
account of peculiar ftates of the human animal ceconomy, or 
on account of fome co-operating agents, the genuine vaccine 
poifon does now and then produce a certain variety of the 
cow-pock, characterifed by the appearance of puftules, like 
thofe of the variola. I have good evidence alfo to fhew, that 
even in the hands of thofe very Inoculators, who a little time 
ago would not allow that the vaccine poifon could produce 
eruptions, fuch cafes have lately“occurred. 
In the month of O&tober laft I inoculated a child two 
years of age with the vaccine poifon. The original mat- 
ter, which had produced this matter, I took from the cow in 
. March laft; fince which time the vaccine difeafe had been 
excited by it, in my hands, in a great number of patients. 
The vaccine difeafe took place with the ufual appearances, in 
the inoculated part, and affected the whole conftitution in the 
ordinary manner; but a few eruptions broke out on the fe- 
cond or third day after the flight fever; they were, however, 
only the red large pimples above mentioned, not at all like 
the fmall-pox. Mr. Keate carried matter from this child to 
Brighthelmftone, where Mr. Barret inoeulated ¢wo children, 
who took the difeafe ; and from one of thefe Mr. Keate ino- 
Sfa2 culated 
