516 On the Eruptions which fometimes appear 
culated ghree children. They all had the ufual fever about 
the eighth day, and all had a number of eruptions, except 
one, which had only five or fix, and thefe dried on the fifth 
day. This laft cafe was probably that which Mr. Keate in- 
forms me had, in the inoculated part, the genuine vaccine 
puftule; but in all the others Mr. Barret obferved that in 
the inoculated part the puftule was ragged at the.edges, and 
flat, more refembling the variolous puftule, Matter from 
thefe patients was fent to Petworth, where Mr. Andre in- 
forms me he inoculated with it fowrtgen children. They all 
took the' difeafe, and had eruptions like the variolous. Three 
children at the breaft had from ¢hree to twelve puftules. 
The remaining e/even children had from fifty to feveral hun- 
dred eruptions. The ftate of the arms, and the characters of 
the puftules of the inoculated part, are not mentioned. None 
of the above patients died, nor is any mention made by Mr. 
Keate, Mr. Barret, and Mr. Andre, even of any apprehenfion 
of danger. Dr. Thornton fent me lately a cafe with eruptions, 
produced by matter which I originally took from a cow. Ac- 
cording, then, to experience, we draw thefe conclufions :— 
t. That in certain conftitutions, or under the circumftances of 
certain co-operating agents, the vaccine poifon produces a dif- 
eafe refembling the fmall-pox; and of courfe the puftule in the 
inoculated part is very different from that of the vaccine pock 
ordinarily occurring, and the eruptions refemble yery much, 
if not exactly, fome varieties of the fmall-pox. 2. That in 
fome inftances thefe eruptions have occurred although the 
inoculated part exhibited the genuine vaccine puftule, 3. That 
the matter of fuch eruptive cafes, whether taken from the 
inoculated part, or from other parts, produces univerfally, or 
at leaft eenerally, fimilar eruptive cafes, and has not, I believe, 
been feet to go back, by paffing through different conftitu- 
tions, to the {tate jn which it produces what is called the ge- 
nuine vaccine difeafe. 4. That eruptions, of a different ap- 
pearance from variolous ones, fometimes occur jn the true 
cow-pock, 
Now, whether the vaccine poifon, when it produces thefe 
cafes refembling the fmall-pox, has really become, by com- 
pofition or decompofition, variglous matter, is undetermined, 
if. 
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