305 On the Vaccine Inoculation. 



On the third or fourth day, one perceives a flight elevation 

 and rednefs; it increafes in a vefieular form till the iath or 

 13th day, and contains always the moft limpid fluid : a fever 

 comes on the eighth or ninth day, or fomctimes is not per- 

 ceptible : the beautiful areola appears on the feventh clay, 

 and incrcafes till the cruft is entirely formed : this cruft be- 

 gins commonly on the twelfth day, and becomes quite black. 



I have had fome cafes originating from count Mottet's 

 matter, where a patient had received the fmall-pox by inocu- 

 lation, and three by natural contagion : one of thefe has re- 

 taken the vaccine in its perfect form. Luckily for the fuc- 

 cefs of the inoculation, the parents of thefe children were 

 advifed previoufly of the idea I had of the imperfection of 

 their former vaccina; and they were not furprifed at it, after 

 having had a great difficulty in believing that the fuperficial 

 cruft that it had formed would be fufficient to preferve them 

 from future infection. 



I have had two cafes where the children were already in- 

 fected with the fmall-pox at the time of the vaccine inocula- 

 tion, and where it fhowed itfclf, as ufual, without interrupt- 

 ing in any degree the courfe of the cow-pock. One of them 

 proved exceffivcly mild; the other is ftill dubious. 



I have had two cafes where the inoculated fpot gave figns 

 of inflammation only on the twelfth clay, and where the pui- 

 tule has been perfectly regular and complete. That was the 

 fame fubjecT: that had been feven months ago inoculated with 

 the imperfect cow-pock. 



I have not yet feen any puflule either of the fugitive or of 

 the variolous -Xikc appearance, although, according to Dr. 

 Woodville's obfervations, they (hould appear more com- 

 monly where the fmall-pox is epidemic. There never was, 

 perhaps, fo difaftrousan epidemic at Vienna as that we have 

 now. It is certainly owing to it that people think fo much 

 now of the cow-pock, againft which thev have been exceed- 

 ingly incredulous. I hope to have it in my power to conti- 

 nue it all winter. By the laft accounts I have of the progrefs 

 o'f the vaccine inoculation at Geneva, it is exceedingly rapid. 

 Some eruptive cafes have lately been obferved there; but I 

 need not enjer into thefe particulate as you will have them 



immediately 



