Report of the National Vaccine Estallishment . 219 



of genuine small-pox, the pustules are augmenting, and the 

 face is betjinning to swell. 2d. The pustules are larcer, 

 and the face much swelled. 3d. The pustules on the face 

 are at the height, and the eyes are nearly closed. 4th. The 

 pustules on the face have all begun to turn; all fever is 

 gone. 



This case is drawn up from the notes of Mr. Moore. The 

 case was visited by several members of the Board, and by 

 many other medical gtuilemen of the highest respectability. 

 From the period at which the violent opposition to small- 

 pox inoculation subsided, till the establishment of vaccina- 

 tion, no reasonable parent has refused to allow his children 

 the benefit of inoculation, although it has been generally 

 acknowledged that the moculation of the small- pox some- 

 times produces a fatal disease; and if at that time the in- 

 stances in which the natural small-pox had occurred after 

 inoculation, had been couimunicated to the public, every 

 intelligent man would undoubtedly have still continued the 

 same course, from a desire of affording his children the best 

 chance of safety, although his confidence in the absolute 

 security from natural small-pox must have been in some 

 degree abated. 



In the same manner, no effect injurious to vaccination 

 ought to result from the knowledge of the above failures. 

 Parents always had been apprised that there were occasional 

 failures of vaccination, but they were al\vays aware that 

 none of their children would die of vaccine inoculation ; and 

 that when it failed, the succeeding small-pox was almost 

 always much mitigated and disarmed of half its terrors. It 

 was natural therefore, that they should choose vaccination 

 as the less dangerous disorder, and the same reason still 

 exists for their perseverance in that choice. If there be 

 constitutions, which are twice susceptible of small-pox, a 

 disorder which produces a violent action upon the human 

 frame, and often destroys life, it is natural to expect that 

 vaccination should not in every instance prevent the small- 

 pox, and that the anomaly which occurs in the one disease 

 should likewise take place in the other. It is ever to be 

 kept in view, that the nund)er of deaths from inoculated 

 small-pox, exceeds the number of failures of vaccination. 

 ,It appears from the present state of our information, that 

 one |)trson in three hundred dies from the inoculated small- 

 pox, and that there is perhaps one failure in a thousand 

 after vaccination. An individual, who, under such cii- 

 cumstances, should prefer the inoculation of his children 

 I'or the small-pux; to submitiing ihem to vaccination, would 



