302 Notices respecting New Books. 



cacious than at a later period ; but it is alleged that no other 

 consequences arise ; tlie presence or absence of the areola fur- 

 nishes no rule independent of the period of the pock. The 

 health does not alter the niaUer. The rule for taking mat- 

 ter should he not according to the day after inoculation, 

 but according to the stale of the pock, — but vsually the most 

 efficacious matter is before the Sth or Qth day: — no mis- 

 chief has been observed from the matter of irregular or ano- 

 malous pocks; but it is liable to fail in producing the due 

 eftcct : — no such matter has been seen as that called spurious, 

 i.e. which produces successively a disease mistaken for the 

 cow-pock, but which does not give security against the 

 small-pox : — no constitutional aflection has been observed 

 on the 5lh day, as asserted on high authority, as well as at the 

 well known period the gth after inoculation. Several in- 

 sertions in the same arm do not excite more inflammation 

 than a single puncture, but they have the advantage of af- 

 fording greater security. — Constitutional afleciions from 

 vaccine and variolous matter have not been observed to co- 

 exist, so that there is no risque from vaccine inoculation 

 when a patient has been exposed to the contagion of the 

 small- pox. — Not one has died ai the Institution, but a few 

 cases have been communicated of death, by inflammation 

 of the arms, and one perhaps by convulsions. A Table is 

 given of the proportional mortality by tlie small-pox during 

 twelve years preceding vaccine inoculation in London ; and 

 another durine the twelve years of the practice of vaccina- 

 tion, to judge of its influence in diminishing the mortality 

 in society by the small-pox. It appears that about 420 

 persons per annum died fewer during the twelve years of 

 the new inoculation, than durins each of the twelve pre- 

 ceding years tiefore its introduction; vet the conclusion 

 that the diniinislied mortality has been occasioned by the 

 cow-pock is liable to error, although the probability is in 

 favour of the influence of the new practice. With regard 

 to the trand question which agitates so much the public 

 mind, and which alarms so much particular families, viz. the 

 security against the small-pox, it appears that out of 3000 

 registered patients who had ail gone through the cow-pock 

 in the nmst distinct manner, nine have subsequently taken 

 the small-pox ; and 40 more failures have been substan- 

 tiated el:?ewhere, exclusive of the hon. Mr. Grosvenor's 

 case, and some others connnunica;ed since this paper was 

 read. 



The very curious new pathological fact is noticed of the 

 failure in particular families, apparently from a congenital 



unsus- 



