438 ANNUAL REPORT SMITHSONIAN INSTITUTION, 194 5 



Harvey Lectures, No. 124, 1938-39), Tiselius (Nova Acta Soc. Sci. Upsal., vol. 4, 

 p. 7, 1930), S0rensen and Haugaard (Compt. Rend. Trav. Lab. Carlsberg, vol. 19, 

 No. 12, 1933), Butler and Montgomery (Journ. Biol. Chem., vol. 99, p. 173, 1932), 

 Butler, Blatt, and Southgate (Journ. Biol. Chem., vol. 109, p. 755, 1935), Kydd 

 (Journ. Biol. Chem., vol. 107, p. 747, 1934), Hewitt (Biochem. Journ., vol. 30, 

 p. 2229, 1936), Stenhagen (Biochem. Journ., vol. 32, p. 714, 1938), Philpot (Nature, 

 vol. 141, p. 283, 1938), Green (Journ. Amer. Chem. Soc, vol. 60, p. 1108, 1938), 

 Fahey and Green (Journ. Amer. Chem. Soc, vol. 60, p. 3039, 193S), Longsworth 

 (Journ. Amer. Chem. Soc, vol. 61, p. 529, 1939), Kekwick (Biochem. Journ., vol. 

 33, p. 1122, 1939), Blix (Zeitschr. Ges. Exp. Med., vol. 105, p. 595, 1939), Svedberg 

 and Pedersen (The ultracentrifuge, Oxford Univ. Press, London, 1940). More 

 recent references describing the fractionation of plasma to yield its diverse 

 components as products for clinical appraisal are Conn, McMeekin, Oncley, 

 Newell, and Hughes (Journ. Amer. Chem. Soc, vol. 62, p. 3386, 1940), McMeekin 

 (Journ. Amer. Chem. Soc, vol. 62, p. 3393, 1940) , Conn, Luetscher, Oncley, Arm- 

 strong, and Davis (Journ. Amer. Chem. Soc, vol. 62, p. 3396, 1940), Cohn (Chem. 

 Rev., vol. 28, p. 395, 1941 ; Trans, and Stud., Coll. Physicians [Philadelphia], ser. 4, 

 vol. 10, p. 149, 1942; Proc Amer. Philos. Soc, vol. 88, p. 159, 1944), and Cohn, 

 Oncley, Strong, Hughes, and Armstrong (Journ. Clin. Inv. vol. 23 p. 417, 1944). 



E. Serum Albumin. 



The chemical properties of albumin are also discussed by Cohn (Chem. Rev., 

 vol. 28, p. 395, 1941 ) , and by Cohn, Oncley, Strong, Armstrong, Ferry, and Hughes 

 (in Mudd, S., and Thalhimer, W., Blood substitutes and blood transfusion, chap. 

 20, Charles C. Thomas, Springfield, 111., 1942), its osmotic pressure by Scatchard, 

 Batchelder, and Brown (Journ. Clin. Inv., vol. 23, p. 458, 1944), and its clinical 

 use by Janeway, Gibson, Woodruff, Heyl, Bailey, and Newhouser (Journ. Clin. 

 Inv., vol. 23, p. 465, 1944), Janeway (Journ. Amer. Med. Assoc, vol. 126, p. 674, 

 1944), Newhouser and Lozner (U. S. Nav. Med. Bull., vol. 40, p. 796, 1942), Stead 

 and Ebert (in Mudd, S., and Thalhimer, W., Blood substitutes and blood trans- 

 fusion, p. 185), Heyl, Gibson, and Janeway (Journ. Clin. Inv., vol. 22, p. 763, 

 1943), Woodruff and Gibson (U. S. Nav. Med. Bull., vol. 40, p. 791, 1942), 

 Kendrick, Reichel, and McGraw, (Army Med. Bull., vol. 68, p. 107, 1943) Janeway 

 (in Mudd, S., and Thalhimer, W., Blood substitutes and blood transfusion, chap. 

 21), Luetscher (Journ. Clin. Inv., vol. 23, p. 365, 1944), Coumand, Noble, Breed, 

 Lauson, Baldwin, Pinchot, and Richards (Journ. Clin. Inv., vol. 23, p. 491, 1944), 

 and Warren, Stead, Merrill, and Brannon (Journ. Clin. Inv., vol. 23, p. 506, 

 1944). 



F. Fibrinogen and Thrombin. 



The proteins concerned in the blood coagulation mechanism have been discussed 

 by a number of authors. Recent reviews are given by Eagle (Medicine, vol. 16, 

 p. 95, 1937), Ham and Curtis (Medicine, vol. 17, p. 413, 193S), Wohlisch (Ergebn. 

 Physiol., vol. 43, p. 174, 1940), Ferguson (Ann. Rev. Physiol., vol. 2, p. 71, 1940), 

 Taylor, Davidson, and Minot (Nelson New Loose Leaf Medicine, vol. 4, Thomas 

 Nelson & Sons, New York), Seegers (Journ. Biol. Chem., vol. 136, p. 103, 1940), 

 Seegers and McGinty (Journ. Biol. Chem., vol. 146, p. 511, 1942), Neurath, Dees, 

 and Fox (Journ. Urol., vol. 49, p. 497, 1943), and Edsall, Ferry, and Armstrong 

 (Journ. Clin. Inv., vol. 23, p. 557, 1944). The purification and properties of 

 prothrombin have been studied particularly by Mellanby (Proc. Roy. Soc London, 

 vol. B 107, p. 271, 1930) and by Seegers (Journ. Biol. Chem., vol. 136, p. 103, 1940). 

 Recent studies on the purification of thrombin have been carried out by Seegers 

 and McGinty (Journ. Biol. Chem., vol. 146, p. 511, 1942) and by Milstone (Journ. 

 Gen. Physiol., vol. 25, p. 679, 1942) . 



