﻿NOGUCHI 
  FLEXNER 
  603 
  

  

  describe 
  them 
  as 
  fully 
  as 
  language 
  permitted. 
  With 
  factors 
  so 
  

   variable 
  in 
  their 
  nature, 
  what 
  he 
  perhaps 
  did 
  not 
  do, 
  and 
  what 
  such 
  

   consummate 
  masters 
  of 
  technique 
  almost 
  never 
  find 
  it 
  possible 
  to 
  do, 
  

   is 
  to 
  put 
  into 
  words 
  those 
  subtle, 
  imponderable 
  yet 
  essential 
  twists 
  

   and 
  turns 
  of 
  method 
  used 
  by 
  them, 
  often 
  unconsciously, 
  in 
  adapting 
  

   a 
  medium 
  to 
  a 
  recalcitrant 
  microorganism. 
  The 
  patient 
  and 
  resource- 
  

   ful 
  among 
  bacteriologists 
  have 
  learned 
  in 
  time 
  to 
  repeat 
  what 
  Noguchi 
  

   has 
  done, 
  but 
  the 
  mass 
  of 
  the 
  conventional 
  among 
  them 
  undoubtedly 
  

   soon 
  tired 
  and 
  gave 
  up 
  the 
  unequal 
  contest. 
  

  

  In 
  1912 
  Noguchi 
  married 
  Mary 
  Dardis, 
  whom 
  he 
  surrounded 
  with 
  

   devotion 
  and 
  who, 
  on 
  his 
  perilous 
  journeys, 
  as 
  we 
  learn 
  from 
  letters 
  

   and 
  cable 
  messages, 
  he 
  had 
  constantly 
  in 
  his 
  mind, 
  lest 
  she 
  suffer 
  

   from 
  undue 
  anxiety. 
  He 
  required 
  few 
  diversions 
  in 
  order 
  to 
  refresh 
  

   his 
  spirit. 
  An 
  occasional 
  game 
  of 
  chess 
  at 
  the 
  Nippon 
  Club 
  or 
  at 
  

   his 
  home 
  or 
  an 
  evening 
  with 
  friends 
  sufl&ced. 
  In 
  the 
  summer 
  at 
  his 
  

   bungalow 
  in 
  the 
  Catskills 
  he 
  fished 
  in 
  the 
  stream 
  which 
  ran 
  beside 
  

   his 
  little 
  place, 
  or 
  he 
  painted 
  in 
  oils 
  in 
  a 
  self-taught 
  manner 
  in 
  which 
  

   there 
  were 
  both 
  talent 
  and 
  charm. 
  In 
  earlier 
  days 
  he 
  was 
  sldllful 
  

   with 
  the 
  brush 
  and 
  produced 
  water-color 
  illustrations 
  for 
  his 
  pub- 
  

   lished 
  papers, 
  which 
  were 
  faithful, 
  finished, 
  and 
  original. 
  As 
  his 
  

   mind 
  was 
  too 
  restless 
  to 
  renew 
  itself 
  by 
  idleness, 
  he 
  found 
  in 
  these 
  

   simple 
  devices 
  means 
  to 
  restore 
  his 
  strength. 
  These 
  avocations 
  were 
  

   followed 
  purely 
  for 
  refreshment, 
  and 
  he 
  always 
  took 
  himself 
  humor- 
  

   ously 
  as 
  painter 
  or 
  sportsman. 
  

  

  The 
  last 
  10 
  years 
  of 
  Noguchi's 
  fife 
  were 
  spent 
  in 
  the 
  investiga- 
  

   tion 
  of 
  certain 
  obscure 
  diseases, 
  including 
  yellow 
  fever, 
  trachoma. 
  

   Rocky 
  Mountain 
  spotted 
  fever, 
  poliomyelitis, 
  rabies, 
  kala-azar, 
  

   and 
  Oroya 
  fever 
  and 
  verruga 
  peruana. 
  It 
  is 
  true, 
  of 
  course, 
  that 
  he 
  

   did 
  not 
  find 
  solutions 
  of 
  all 
  these 
  riddles 
  of 
  pathology, 
  but 
  the 
  re- 
  

   markable 
  thing 
  is 
  rather 
  that 
  he 
  should 
  have 
  solved 
  as 
  many 
  of 
  

   them 
  as 
  he 
  did. 
  

  

  There 
  was 
  a 
  logic 
  in 
  Noguchi's 
  work 
  which 
  is 
  not 
  always 
  perceived 
  

   immediately 
  by 
  readers 
  of 
  his 
  monographs 
  and 
  many 
  papers. 
  As 
  a 
  

   matter 
  of 
  fact 
  he 
  was 
  always 
  capitalizing 
  and 
  refining 
  his 
  experience. 
  

   He 
  learned 
  that 
  the 
  gonads 
  of 
  the 
  rabbit 
  not 
  only 
  serve 
  to 
  grow 
  the 
  

   syphilis 
  spirochete 
  in 
  great 
  numbers, 
  but 
  also 
  to 
  free 
  them 
  of 
  asso- 
  

   ciated, 
  contaminating 
  bacteria. 
  His 
  studies 
  on 
  Rocky 
  Mountain 
  

   spotted 
  fever 
  emphasized 
  further 
  the 
  suitability 
  of 
  these 
  organs 
  to 
  the 
  

   abundant 
  multipHcation 
  of 
  even 
  undetermined 
  microorganisms. 
  He 
  

   therefore 
  employed 
  the 
  method 
  to 
  enrich 
  and 
  purify 
  vaccine 
  virus, 
  

   and 
  thus 
  for 
  the 
  first 
  time 
  secured 
  this 
  important 
  material 
  in 
  an 
  

   uncontaminated 
  state. 
  The 
  neuro 
  vaccine, 
  so 
  widely 
  employed 
  in 
  

   Europe 
  for 
  vaccination 
  is, 
  of 
  course, 
  a 
  direct 
  outgrowth 
  of 
  Noguchi's 
  

   discovery, 
  as 
  are 
  many 
  of 
  the 
  studies 
  now 
  in 
  progress 
  in 
  which 
  partic- 
  

   ular 
  organs 
  of 
  hving 
  animals 
  are 
  used 
  to 
  procure 
  evidences 
  of 
  the 
  

   presence 
  of 
  parasitic 
  organisms 
  in 
  diseases 
  of 
  unestablished 
  origin. 
  

  

  