﻿606 
  ANNUAL 
  REPORT 
  SMITHSONIAN 
  INSTITUTION, 
  192 
  9 
  

  

  cultures. 
  He 
  decided 
  not 
  to 
  overlook 
  any 
  microorganism, 
  no 
  matter 
  

   how 
  banal 
  it 
  appeared 
  to 
  be. 
  This 
  determination 
  in 
  itself 
  is 
  illuminat- 
  

   ing 
  as 
  to 
  Noguchi's 
  method 
  of 
  attacking 
  a 
  new, 
  complex 
  problem. 
  

   To 
  most 
  bacteriologists 
  the 
  labor 
  involved 
  would 
  seem 
  not 
  only 
  futile 
  

   but 
  devastating. 
  Just 
  here 
  we 
  observe 
  not 
  only 
  the 
  rigid 
  system 
  of 
  

   research 
  which 
  Noguchi 
  had 
  developed, 
  but 
  we 
  note 
  also 
  the 
  effect 
  of 
  

   his 
  incomparable 
  industry, 
  because 
  the 
  mere 
  technical 
  operations 
  of 
  

   the 
  plan 
  proved 
  prodigious. 
  They 
  did 
  not, 
  however, 
  abate 
  his 
  deci- 
  

   sion, 
  and 
  the 
  end 
  result 
  is 
  that 
  he 
  discovered 
  a 
  new 
  bacterial 
  species 
  

   called 
  Bacterium 
  granulosis, 
  which 
  on 
  injection 
  into 
  the 
  conjunctival 
  

   mucous 
  membrane 
  of 
  the 
  chimpanzee, 
  baboon, 
  and 
  Macaca 
  rhesus 
  

   induces 
  a 
  chronic 
  granular 
  infection, 
  which 
  clinically 
  and 
  pathologically 
  

   is 
  indistinguishable 
  from 
  trachoma 
  in 
  man. 
  From 
  the 
  inoculated 
  

   conjunctiva 
  of 
  one 
  eye 
  the 
  granular 
  infection 
  spreads 
  of 
  itself 
  to 
  the 
  

   uninoculated 
  other 
  eye. 
  This 
  experimental 
  trachoma 
  in 
  monkeys 
  

   persists 
  for 
  many 
  months, 
  gradually 
  producing 
  in 
  certain 
  animals 
  the 
  

   deforming 
  scarlike 
  changes 
  so 
  commonly 
  met 
  with 
  in 
  man. 
  As 
  is 
  so 
  

   common 
  an 
  experience 
  when 
  a 
  disease 
  native 
  in 
  one 
  animal 
  species 
  is 
  

   grafted 
  on 
  a 
  species 
  in 
  which 
  it 
  does 
  not 
  naturally 
  occur, 
  there 
  are 
  

   certain 
  distinctions, 
  usually 
  of 
  intensity, 
  to 
  be 
  detected, 
  but 
  the 
  essen- 
  

   tial 
  trachomatous 
  process 
  arises 
  in 
  the 
  monkeys 
  as 
  the 
  result 
  of 
  the 
  

   inoculation 
  of 
  a 
  particular 
  bacterial 
  species 
  hitherto 
  unknown, 
  and 
  

   obtained 
  by 
  Noguchi 
  from 
  undoubted 
  cases 
  of 
  trachoma 
  as 
  it 
  exists 
  on 
  

   a 
  wide 
  and 
  destructive 
  scale 
  among 
  the 
  American 
  Indian 
  population. 
  

  

  From 
  time 
  to 
  time, 
  Noguchi 
  undertook 
  the 
  investigation 
  of 
  other 
  

   problems 
  than 
  those 
  already 
  noted, 
  with 
  which 
  he 
  made 
  progress. 
  

   Thus 
  the 
  cultivation 
  of 
  the 
  "globoid 
  bodies" 
  from 
  the 
  filter-passing 
  

   virus 
  disease 
  poliomyelitis 
  was 
  a 
  definite 
  achievement. 
  He 
  contri- 
  

   buted 
  to 
  the 
  knowledge 
  of 
  Rocky 
  Mountain 
  spotted 
  fever, 
  both 
  in 
  

   respect 
  to 
  the 
  Rickettsia-like 
  organisms 
  present 
  in 
  the 
  insect 
  vector, 
  

   the 
  wood 
  tick, 
  and 
  in 
  human 
  tissues, 
  and 
  also 
  in 
  respect 
  to 
  an 
  anti- 
  

   serum 
  capable 
  of 
  neutralizing 
  the 
  virulent 
  incitant, 
  and 
  thus 
  making 
  

   the 
  effective 
  treatment 
  of 
  the 
  fatal 
  disease 
  a 
  matter 
  of 
  hopeful 
  further 
  

   pursuit. 
  His 
  study 
  of 
  the 
  protozoan 
  organism 
  causing 
  kala-azar, 
  a 
  

   disease 
  of 
  the 
  eastern 
  world, 
  led 
  to 
  the 
  perfection 
  of 
  methods 
  for 
  cul- 
  

   tivating 
  the 
  class 
  of 
  flagellated 
  organisms 
  and 
  among 
  them 
  the 
  inter- 
  

   esting 
  species 
  inhabiting 
  the 
  latex 
  of 
  the 
  milkweed, 
  which 
  are 
  found 
  

   also 
  in 
  the 
  intestines 
  of 
  the 
  insects 
  feeding 
  on 
  the 
  milk. 
  Having 
  

   secured 
  a 
  wide 
  variety 
  of 
  flagellates 
  in 
  pure 
  culture, 
  he 
  developed 
  

   methods 
  for 
  their 
  distinction 
  by 
  serological 
  and 
  other 
  means 
  such 
  as 
  

   are 
  used 
  in 
  the 
  differentiation 
  of 
  bacteria. 
  

  

  In 
  October, 
  1927, 
  Noguchi 
  sailed 
  for 
  Africa. 
  This 
  was 
  the 
  consum- 
  

   mation 
  of 
  a 
  wish 
  he 
  had 
  long 
  entertained, 
  but 
  which 
  uncertain 
  health 
  

   had 
  caused 
  to 
  be 
  deferred. 
  He 
  wished 
  naturally 
  to 
  study 
  and 
  compare 
  

   the 
  yellow 
  fever 
  of 
  Africa 
  with 
  that 
  of 
  South 
  America. 
  The 
  investi- 
  

  

  