by the administration of Arsenious Acid. 215 
had reached the normal quantity. On administering the pre- 
vious dose, the quantity diminished to 1:27 grm. 
With a cat weighing 2°61 kilogs., and which consumed daily 
130 grms. of flesh, the normal respiration was 3-08 grms. 
0-025 grm. AsO? were injected into the jugular vein ; the quan- 
tity fell to 2301 grms., and subsequently the animal died. 
With another cat the average respiration of carbonic acid in an 
hour was 2°925 grms., and the average amount of urea secreted 
per diem was 9°85 grms. After the administration of 9°01 grms. 
AsO®, the respiration sank to 1°98 grm., and the secretion of 
urea to 3°61 grms. 
With starving animals, previous investigations (by Bidder and 
Schmidt) showed that the respiration diminishes in the first 
forty-eight hours, but afterwards remains constant even until the 
sixteenth day, notwithstanding the continuous decrease in weight 
of the animal. To ascertain the effect of arsenious acid upon 
starving animals, the following experiments were made. A cat 
whose respiration amounted to 3°3 grms., was left without food 
for three days. On the first day the respiration had sunk to 
2°45, and on the third to 2°24 grms. 0-018 grm. As O° were 
then injected into the jugular vein. The respiration of CO? de- 
creased to 1:902 grm. The action of the heart also diminished 
greatly. 
In another experiment with a cat weighing 3°31 kilogs., and 
fed on 150 grms. flesh daily, the respiration and the secretion 
of urea were determined for four days. The animal was then 
deprived of food, and the same determinations made for the 
same time. The weight and the secretion of urea remained 
constant for the first four days; during the next four days the 
weight diminished to 2°88 kilogs., and the respiration of carbonic 
acid from 3°45 grms. to 2°54 grms. An injection of 0-005 grm. 
As O? into the jugular vein was then made, and the animal fed 
with meat, which it consumed with great avidity, but afterwards 
vomited all but 24grms. On the following day it refused food. 
The respiration of CO? diminished to 2-24 grms., while the bodily 
weight slightly increased, and underwent no diminution until the 
third day after the injection, during which time the animal rejected 
all nourishment. ‘This result is the more surprising since, in the 
earlier period of inanition, fasting for twenty-four hours produced 
a considerable diminution in the bodily weight. 
From these experiments, Schmidt and Stiirzwage conclude 
that arsenious acid introduced into the organism occasions a 
considerable diminution in the secretion of matter. The phe- 
nomena are most observable in fowls; but even in cats, which 
vomit after the injection, and are to be considered as starving, 
the diminution amounts to 20 per cent., even after eliminating 
2 
