new Polarizing Crystals produced from Quinine. 191 



Therefore we now have found — 



A. B. Calculated. Per cent. At. 



Iodine . . 32-6092 3] -453 124 Iodine . . 32-63 1 

 Sulph. acid 10-612 10-844 40 Sulph. acid 10-52 1 

 Alkaloid . 42-692 162 Quinine . 42-63 1 



Water . . 14-1764 54 Water . . 14-2152 6 



- 1000896 380 99-9952 



These results correspond veiy closely with the formula 

 (C20Hi2NO2 + I) + SO3 + 6HO; and as it has been previously 

 proved that the base is not a substitution compound, it only re- 

 mains to consider it as a salt in which iodine is superadded to the 

 base quinine without interfermg with its basic properties, how- 

 ever much it may alter its chemical characters. Experiments 

 have been instituted to produce this iodo-quinine in an isolated 

 state, but hitherto without success, — the nearest approach hi- 

 therto made is by the action of ammonia at 60" Fahr., — by care- 

 fully triturating the polarizing crystals in the strongest Liquor 

 Ammonise during half an hour, separating on a filter, washing 

 with cold distilled water, and carefully di-ying the reddish-yellow 

 mass produced : this contained nearly all the iodine and quinine, 

 but the ammoniacal solution contained sulphate of ammonia; 

 some of the resinous compound dissolved in it, together with 

 about 11-0 per cent, of hydriodate ammonia. The resinous mass 

 was treated with diluted sulphuric acid, in order to attempt to 

 produce the polarizing crystals again; they certainly were re- 

 produced, but not in a satisfactory manner ; some other com- 

 pounds were also produced, the formation of which cannot be 

 accounted for in the present condition of the question. 



The alkaloid separated by the previously detailed analysis was 

 then examined. From it was first made the disulphate; this 

 differed materially from disulphate of quinine, both in its cry- 

 stalline form and its solubility ; it would dissolve in about three 

 times its weight of water at 212^, crystallizing in radiating plu- 

 mose tufts, very similar to acetate of morphia in appearance. 



From this disulphate were reproduced the polarizing crystals 

 very readily upon submitting it to the same operation as was 

 originally used, namely, solution in acetic acid, and then adding 

 an alcoholic solution of iodine to the heated fluid; on cooling, 

 the green crystals deposited, having their original extraordi- 

 nai-y ])roperties. The disulphate of the alkaloid differed as 

 much in its ojitical as in its chemical characters from quinine ; 

 assimilating itself in the former to the disulphate of quini- 

 dine (/9-quinine), whereas the ])urc alkaloid much more re- 

 sembled quinine in its chemical characters, as it is soluble both 

 in alcohol and in aether, but crystallizes from neither with faci- 

 lity; some slight appearance of crystallization is obtained by 



