of the Spigelia Marilandica. 75 



thrown up part of her dose, soon after she had taken 

 it. They gradually became like persons intoxicated 

 with spirituous liquor, staggering about, talking inco- 

 herently and deliriously. After continuing in this 

 way for near four hours, they both went to sleep, and 

 when they awoke, they were free from every percep- 

 tible complaint, excepting slight sickness at stomach, 

 which soon went off, and, next day, they were per- 

 fectly well. 



" While they were under the inebriating effects of 

 the medicine, the pupils of their eyes appeared very 

 much enlarged ; but I did not observe the convulsive 

 motion of the muscles of the eyes, mentioned, by Dr. 

 Lining, as a common occurrence of an over-dose of 

 Spigelia." 



Philadelphia, February 15 th, 

 1805. 



XII. Notice of the Epidemic Fever, which prevailed hi 

 Tork-Toivn, and the adjacent country, in the autumn 

 of 1804. In a letter from Dr. John Spangler, 

 to Dr. Currie. Communicated to the Editor, by 



. Dr. Currie. 



Sir, 



DURING the autumnal months, there pre- 

 vailed, in this town and its vicinity, a bilious remit- 

 ting fever, assuming, in some instances, a typhous, 

 and, in many instances, towards the close of the sea- 



