82 Inefficacy of Faccine 'Inoculation. 



effect ; but, on reading my paper, inoculated it a fourth time, and 

 the child liad llic buiall-pox. 



I have the positive authority of Baron Dimsdale lo say, the 

 natural small-pox never occurs a second time. 



J. B. 



XIII. Facts and Observations relative to Small- Pox 

 and to (Variolous) Inoculation. By Dr. Frank- 

 lin*, and by the late Mr. George R. Minot, of 

 Boston. 



INOCULATION was first practised in Bos- 

 ton bv Dr. BoYLSTONE in 1720. It was not used 

 before in any part of America, and not in Philadelphia 

 till 1730. Some years since, an enquiry was made 

 in Philadelphia of the several Surgeons and Physi- 

 cians who had practis'd Inoculation, what numbers 

 had been by each inoculated, and what was the suc- 

 cess. The result of this enquiry was, that upwards 

 of 800, (I forget the exact number) had been inocu- 

 lated at different times, and that only four of them 

 had died. — If this account was true, as I believe it 

 was, the reason of greater success there than had 

 been found in Boston, where the general loss by Ino- 

 culation used to be estimated at about one in 100, 

 may probably be from this circumstance; that in 

 Boston they always keep the distemper out as long as 

 they can, so that when it comes, it finds a greater 

 number of adult subjects than in Philadelphia, where 



• In 175?. 



