174 " Revietv. 



" July 13, 1801, I vaccinated Nicoletta Santoro, aged 

 eight months, living in the street called Conce. On 

 the 19th of the same month, -whilst the vaccine pus- 

 tule .sho^ved itself on the incision, two others appeared 

 on the anterior muscles of the right thigh, another on 

 the left, and a fourth near to the nipple of the left breast, 

 surrounded by the usual redness, flat, with the edges ele- 

 ^^ated, equal in every respect to the true vaccina. I was 

 induced to prove the inoculation with virus taken from 

 one of these pustules. In fact, on the 22d of tlie same 

 month, I punctured one of the pustules which appeared 

 on the anterior part of the right thigh, and vaccinated 

 Caterina Barucheri, aged seven months, Anna Catalono, 

 aged one year and eight months, and Paolo Manno, of 

 five months. 



" On the 26th, having examined them, I saw that 

 the two first only had taken the vaccina. I did not 

 cease to examine them daily, and ascertained, that in 

 both, a true vaccina had discovered itself, with a regular 

 and uniform course. 



" May 16th, 1801, I vaccinated an infant of one year 

 and seven months. On the 22d, I did not observe any 

 siffn of the vaccina. I returned to vaccinate it on the 

 28ch, and, after the fourth day of the second inoculation, 

 the second incision not only manifested itself, but the. 

 first likewise. Both dried up on the twclftli day from 

 the last vaccination. 



" A change in tlic axillary gland always accompanies 

 inflammation, and the suppuration of the vaccina. But 



