Meviexu. I75 



sometimes it becomes swelled, and painful more than 

 usual. I have also frequently observed an alteration in 

 the inguinal glands*. Another particular phenomenon 

 happened in the person of Don Philip RufFo, aged three 

 ' years, vaccinated by me, December 19, 1801. On the 

 27th, whilst the vaccine pustule appeared, the axillary 

 glands were not only affected, but the inguinal also; and 

 was attacked with slight convulsions, as are usual in the 

 natural small- pox. It frequently happens, that the vac^ 

 cination remains without producing any effect, and it be- 

 comes necessary to repeat it many timesf. Notwith- 

 standing I repeated it more than once, and used the 

 most scrupulous diligence, it was not possible to sue- 

 ceed in producing it. Marshall vaccinated Don Gae- 

 tano Gandolfo, aged two years, four times, with all 

 possible care, without effect. In the course of four 

 months after, he was vaccinated by me, and the true 

 vaccina very soon appeared. 



" Six other observations, made, with the greatest care, 

 on subjects of different ages and temperaments^ vacci- 

 nated, more than once, in different parts of the body, 

 with vaccine virus always different, and taken at differ- 

 ent periods of the disease, have led me to think, that the 

 production of the vaccina depends not only on attention 

 in the practice, or on the activity and quality of the virus, 

 but also on a certain aptitude of the body of the person 

 to be vaccinated. 



* 1). Valentino Guarncri, D. Guiseppe Cuomo, Rosa lo Piccolo. 



t VVc ou(jht not lo repeat the operation more than four or five 

 times, and not imitate ix /i/n/.ucian, who inoculated his own chil- 

 dren nineteen times, without effect. 



