in the Malignant Yellow-Fever. 105 



It appears from his observations and proofs, that the 

 efficacy of the cure may be totally and wantonly de- 

 stroyed, if some of the doses are omitted, or the first 

 hours neglected, in which it should be administered. 

 Of ninety-seven persons who were attacked with this 

 fever, in the village of Barreos, and who took these six 

 or eight ounces of bark, within forty-eight hours of the 

 attack, commencing from the first to the eighth hour, 

 all quelled the disorder in its origin, one excepted, who 

 perished, having at the same time an attack of the gout. 

 Of eight who took the same quantity, commencing from 

 the eighth to the tenth hour, all were cured. Of five, 

 who began to take it from the tenth to the twenty-fourth 

 hour, three recovered, and two died. Of twenty, who 

 began the second day, thirteen recovered, and seven died. 

 Of seventeen, who began the third and fourth days, eight 

 recovered, and nine died; and, finally, of eighty-nine 

 who were treated as they chose, but in a different man- 

 ner (including the sudorific plan), only twenty-two re- 

 covered. It is further to be observed, that when no 

 time was lost in beginning the bark, within the first ten 

 hours, and taking the six or eight ounces, the disorder 

 was so completely suffocated and eradicated, that the 

 cure was effected by the fourth day, and they were able 

 to leave the house, as if they had not been sick, and be- 

 fore the second and most terrible period of this disor- 

 der, which usually commences the third day. But 

 when there was delay as to time in the commencement, 

 or neglect as to the quantity, they felt proportionably 

 more or less of the symptoms of the second period, 

 and risked more or less from their violence, although 

 they were finally cured. 



