On Cutaneous Absorption. 297 



this time was pale, nor was it in the least altered by the 

 addition of the potash. Two hours and a half after I 

 took the madder, the urine was considerably tinged, 

 and, on the addition of the potash, it assumed the 

 bright cranberry hue. Five hours from the time the 

 madder was taken, the urine had a deeper colour than 

 the last mentioned portion, and, with the potash, it 

 gave a proportionably deeper- coloured result. Treated 

 with the sulphat of iron, it assumed the purplish-brown 

 tinge. The urine discharged the following morning 

 was of a faint red, and was perceptibly changed by the 

 potash. The pulse in the two last experiments was 

 somewhat accelerated, owing either to the madder or 

 to exercise — more probably to exercise. I had no 

 head- ache. 



EXPERIMENT XIII. 



I made an infusion of two pounds and a half of the 

 best madder in about thirty gallons of water. April 4, 

 at half past 2 o'clock, P. M., I entered this infusion, 

 and remained in it until half past 6 o'clock, P. M. 

 The temperature of the atmosphere was 68°, that 

 of the bath fluctuating from 85° to 87°. In con- 

 sequence of considerable previous exercise, my pulse 

 stood at 100 beats in a minute, at the time of en- 

 tering the bath. In half an hour it was 87 in a mi- 

 nute ; in an hour and a half it was 79 ; in two and a 

 half it was at 76 ; in three and a half it was at 72 ; and 

 in four hours it was at 68 in a minute. 



