14 Dr. Rousseau on the 
There are six cases (two quotidian, three tertian, one 
quartan,) cured by one dose, of two or three gros each, of 
the powder of the holly. 
There are ten cases (three quotidian, four tertian, three 
quartan,) cured by two doses of the same. 
There are twenty cases (seven quotidian, seven tertian, six 
quartan,) cured by three doses of the same. 
There are eight cases (three quotidian, one tertian, four 
quartan,) cured by four doses of the same very valuable me- 
dicine. 
Case of Nervous Fever, complicated with daily Paroxysms of 
Ague, treated successfully by the author of this Memoir, by the 
use of Ilicine, a substance which he discovered in May 1831. 
Bataille, a youth, aged eleven years, of a nervous habit, residing 
in Paris for the prosecution of his studies, was entered on the sick 
list on the Ist of June, 1831. This lad complained of a violent 
headach, cough, and much heat of the abdomen; but these symp- 
toms were not thought sufficient to confine him to his room, and 
his medical attendant permitted him to rejoin his class. Being 
thus neglected, the fever increased in severity, and became mani- 
festly of a typhoid character. On the 27th of June, it was com- 
plicated with an attack of ague, which came on about four or five 
o'clock in the afternoon ; the paroxysm lasted two hours and a half. 
On the 28th the attack returned at eight in the evening; and on 
the 29th at ten in the forenoon. 
I saw the patient at four p.m. in consultation with my colleague 
Dr. Lonces-ViLLeRMay. The following were the most prominent 
symptoms: weakness of the back, much prostration of strength, 
and general apathy; pupils much dilated, and very little contrac- 
tile; teeth slightly covered with sordes; mucous rattle in the 
upper lobes of both lungs; abdomen very hot; urine scanty, and of 
a red colour; pulse 110 to 120 per minute. 
The paroxysms continued to recur daily to the 9th of July, with 
equal severity, and always commencing with coldness of the feet. 
Dr. Longes-Villermay proposed the administration of quinine, but 
I was anxious to employ the febrifuge principle of the holly-leaves, 
which I had lately discovered, and on Saturday, 9th July, at eight 
p.m. a pill containing six grains of ilicine was given to the boy, who 
had a quiet night; he also took at the same time some liquorice 
powder. 
July 10th, at six p.m, The six-grain ilicine pill was repeated ; 
the shivering fit, however, came on, lasting two hours and a half, 
and the hot stage equalled it in length. 
llth. Medicines repeated. The cold stage of the intermittent 
commenced at two o’clock, and lasted but two hours. The hot 
stage, however, did not terminate till a quarter to eight in the 
evening. 
J 
