8 Dr. Rousseau on the 
liver and spleen; and cedema of the limbs. I ordered half a gros 
of the alcoholic extract of the leaves of the holly, to be taken in 
two doses, three hours before each paroxysm. The first dose caused 
the paroxysm to continue only one hour, instead of four; the se- 
cond-dose, taken two days after, effected a cure. These two doses 
produced six evacuations from the bowels. 
Case VIII. M. Adlard, aged thirty and some years, was at- 
tacked, in 1828, with a tertian intermittent, when employed in a 
porcelain manufactory: he was ordered two grains of tartar emetic, 
and was bled several times. The fever still continuing, cinchona 
bark was given in its various forms, which not only created nausea, 
but irritation of the stomach. The sulphate of quinine was given in 
boluses, of which he took (according to his own account) 150, four 
of them morning and evening; did not know the quantity of qui- 
nine in each bolus; these effected an intermission of the paroxysms 
for four, six, and even eight days. At last quinine lost its effect. 
Hepatitis set in by the continued use of this salt; the least pressure 
in the region of the liver caused extreme pain, so that he could 
not endure the weight of the bedclothes, nor even of his shirt. 
He was advised, at the end of nine months, to leave Champeroux, 
which was surrounded by marshes: he came to Paris, and consulted 
me, two months after his arrival, the 25th February, 1829. The 
fever had then not diminished in the least; there was great weak- 
ness; eyes sunk, and slightly yellow; nostrils contracted; lips 
discoloured; skin generally of a yellow leaden colour; walks with 
difficulty; loss of appetite; costive and scanty evacuations from 
bowels; urine of asaffron colour. Jn this state, I ordered him two 
gros of the powdered leaves, in vinous infusion, to be taken two 
hours before the paroxysm, which retarded its access from six o’clock 
A.M. to midday. On the 26th, he had a better appetite than here- 
tofore; but the fever returned on the 27th, at two o’clock p.m. 
He then took the same dose as before on the Ist March, and the 
paroxysm did not appear until six o’clock p.m., but was severer 
than the last. The liver, however, became diminished in size, and 
he had a greater relish for his meals. ‘The paroxysm returned on 
the 3d at midnight; also the 5th. Gave him a third dose on the 
9th, of two and a half gros of the powder, which completely 
checked the fever for six days. This dose produced four very fetid 
alvine evacuations; after which, the patient walked with greater 
facility, and the irritability of the liver decreased greatly. On 
the 15th and 18th, paroxysms returned, but were milder. On 
the 24th, took a fourth dose of three gros. On the 27th, he took 
the fifth and last dose, which completely subdued the fever. I 
saw him on the 8th July, perfectly recovered; stomach, liver, skin, 
&c. performing their functions normally. This was the severest 
case | have ever seen: I never ordered before such large doses of 
the Ilex Aquifolium. 
I also attended the wife of this person, who had had ninety 
leeches at three times applied to the epigastrium, and had taken 
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