Holly and Tlicine. 7 
Case III. In 1820, Madame Thuillies was aMiicted for six months 
with an intermittent fever: I advised her to try the effect of the 
holly-leaves, and gave her the powder as above described. Three 
doses of infusion, each containing one gros of the powder, cured 
her. 
Case IV. Madame Cocher, a dairywoman at Ivrey, near Paris, 
had a quotidian intermittent, for which she was ordered, by a dis- 
tinguished surgeon, cinchona bark in powder, sulphate of quinine, 
and wine of Seguin, twice an emetic, &c., without the least relief. 
She had suffered with this attack for two months and a half 
before she consulted me: when I saw her, her face was pale, and 
of a leaden hue; eyes yellow; lips discoloured; tongue yellow; 
appetite lost; liver enlarged and painful; inferior extremities ede. 
matous; and she could scarcely support herself in the erect posi- 
tion. I ordered her two doses, of two gros each, of the same powder 
infused in wine: the first of which changed the fever to the tertian 
type, and somewhat restored the appetite. The second dose, which 
was taken the day after the next paroxysm occurred, produced four 
alvine evacuations, and entirely cured the fever. 
Case V. Joli, aged twenty-one, a labourer at Ivrey, and living 
in the same district with the milkwoman whose case is detailed 
above, was treated in a similar way, and by the same surgeon, ex- 
cepting that he was bled twice; but all without any good effect, 
Three doses of the powder of holly-leaves, of two gros each, were 
administered. The two first prevented the return of the paroxysms 
for eight days; and after the third the fever never recurred, 
Case VI. M. Despoi, 55, Quai de la Rapée, afflicted with 
a tertian intermittent during three months, consulted me, June, 
1827; he had previously taken cinchona bark in partes and the 
sulphate of quinine. He complained of pain in the epigastrium, 
which prevented him from walking. The right side was extremely 
painful to the touch, and I felt, between the liver and stomach, a 
considerable swelling, deeply seated, which I believed to be a 
greatly enlarged pancreas; the liver also was more voluminous 
than natural, and morbidly sensible. Three doses, of two gros 
each, of the holly powder steeped in white wine, restored the pa- 
tient, so that he had no further relapse of the fever; and the tumour, 
which I decided to be an enlarged pancreas, gradually disappeared, 
and the liver lost its preternatural sensibility. 
Case VII. Madame M., a lady living at Bondy, was attacked, 
while walking, in the spring of 1828, with a sudden shivering along 
the spinal column, which continued for two hours, and was followed 
by the hot dry stage, and this by the profuse sweating of ague. 
Similar paroxysms continued to return daily at the same hour for 
a month, notwithstanding the administration of five grains increased 
to fifteen grains of sulphate of quinine daily, of two bleedings, and 
the application of twenty-four leeches to the pit of the stomach. 
When I was consulted, the 15th June, the face was of a livid yel- 
low colour; eyes yellow; lips blanched; pain in the region of the 
