6 Dr. Rousseau on the 
3. In extract, it is given in doses of one half to one gros, 
as a bolus or in the form of pill; or the quantity can be in- 
creased to one half, if the pertinacity of the fever should 
render such increase necessary. 
4, Asilicine. This febrifuge principle, in which the bitter 
matter of the plant resides, should be administered in doses 
of six, twelve, eighteen, or twenty-four grains, in the form of 
pills, as least disagreeable to the patient, and the use of it 
continued until the disease is entirely subdued. 
5. In injection. 'This mode of administration originated 
with Dr. Constantin, already mentioned: he recommends 
half an ounce of the leaves, either dry or freshly gathered, 
to be boiled for about a quarter of an hour, in a sufficient 
quantity of water to form a clyster. These injections, be- 
sides their febrifuge effects, have the accompanying advan- 
tage of producing free evacuations from the bowels, without 
pain or griping. Dr. Serrurisr has likewise prescribed the 
holly in the form of enemata, and his experience coincides 
with that of Dr. Constantin, both having been equally suc- 
cessful. Many cases furnished by this physician are embo- 
died in this report. The clinical observations of Professor 
Macenpte have likewise furnished many conclusive facts in 
favor of the efficacy of this medicine, although they have not 
been communicated in all the detail that they deserve. 
The following cases will give, I hope, a decided proof of 
the febrifuge action, as well as sedative powers of the leaves 
of the Ilex Aquifolium upon the spleen, liver, and pancreas, 
especially when the sensibility of these organs has been in- 
creased by the use of the cinchona and its compounds; 
phenomena which, I think, have only been observed by me, 
and upon which, nevertheless, I am of opinion that the pro- 
tracted duration of intermittent fever in great part depends. 
Case I. John Louis Auscar, aged twenty, coachman, was at- 
tacked with a quotidian intermittent fever, the 26th July, 1816, 
which he said was caused by taking a bottle of beer when he was 
warm. He entered the Hotel Dieu, and having left it without re- 
ceiving any benefit by the treatment he there received, he con- 
sulted me the 4th November, 1816, (four months after the first 
attack of fever.) I ordered him to take one gros (in infusion) of 
the leaves of the holly, two hours before each paroxysm. The 
second dose cured him, within forty-eight hours. J saw him fifteen 
days after, and he was quite restored to health. 
Case II. A lady, of lymphatic temperament, aged eighteen, 
afflicted for twelve days with a double quotidian intermittent, in 
March, 1818. She took half a gros of the same powder, infused 
in a glass of white wine, before the paroxysm: one dose sufticed 
to effect a cure. 
