406 Scientific Intelligence. {[May, 
send it opened, and wish you would be so kind as to put a wafer in 
it, and suffer the penny post to convey it to him. The curiosity, 
nay anxiety of the public, especially of parents, on this subject, is 
very considerable. We indeed feel anxious ourselves, as four of our 
six children have never been innoculated.” 
Nov. 18, 1800. 
*¢ T am in no small tribulation for want of the vaccine matter. I 
introduced it into this country ; but some how or other it has de- 
preciated in my hands. It fails in more than half I have innocu- 
lated for several weeks past. I never received any but from Dr. 
Haygarth, which was last June. 
‘¢ I have never been able to procure Woodville’s last publication 
on the cow-pox. Are there any good practical treatises recently 
ublished on this subject? As 1 was the first who introduced it 
fire I am applied to from all quarters, but am chagrined almost 
to sickness, because I have no confidence in the matter I possess. 
The vaccine poison has become milder by passing through a number 
of the human species, or else the cold weather has deprived it of 
half its venom. As soon as I receive fresh matter from England, I 
will directly innoculate a cow, by way of obtaining active matter 
from the fountain head. 
“© T have had several instances in the cow-pox where the symp- 
toms came on pretty violently in 24 hours. In many instances I am 
puzzled to know whether the patient has really gone through the 
disease, so as to secure him from further infection. My situation is 
peculiarly perplexing; for should any unfortunate case occur under 
any practitioner, I shall bear the blame of it. I have diffused the 
matter all over the country, and am conscious that it has degene- 
rated and become spurious. Applications by letter and otherwise 
crowd upon me every hour, and almost every minute, to solve 
doubts, give directions, and console disappointments ; and I have 
no person to apply to myself, for the information which I feel I 
myself stand in need of. I have Fenner’s work, first and second 
part; Woodville’s first publication ; and Pearson’s first pamphlet ; 
and the second volume of the Medical and Physical Journal; and 
could wish that Mr. Mawman would send me any thing and every 
thing that has or may come out in the course of the winter which 
you can recommend.” 
Dec. 13, 1800. 
« As I know not Dr. Jenner’s address, I have enclosed a letter 
which I would thank you to forward to him as soon as possible. I 
have written to him on a subject in which J am deeply interested, I 
mean the cow-pox. You already know, perhaps, that I introduced 
that distemper here, and led the way in its innoculation, and that 
very much to my advantage; but it has lately worked very per- 
versely, and occasioned me much perplexity. Since the cold, raw 
weather of November came in, the maéter has deteriorated in my 
hands, and in the hands of every one else, so that almost all the 
cases that have lately occurred have proved spurious; and unless I 
