[Vor. 3 
260 ANNALS OF THE Missourt BOTANICAL GARDEN 
ding of the mycelium or derived by the germination of 
chlamydospores. The aset contain four ascospores, formed 
in a manner similar to those of E. capsularis, slightly reni- 
form, 2.83.5 x 1.75-2 x 12-14, with a thick membrane. 
The germination of these ascospores has not been observed. 
Development takes place at a temperature of 20-39°С. 
on slightly acid, solid, or liquid media. In sugar solutions 
and fruit juices growth takes place slowly, with the formation 
of а flocculent deposit but with no film on the surface. The 
fungus coagulates milk after 20-30 days and ferments dex- 
trose slightly. Certain authors believe that there exist many 
varieties of E. albicans, only some of which have the func- 
tion of producing spores. 
Castellani (711) isolated from cases of bronchomycosis in 
Ceylon, twenty-two strains of Епфотусез which, in micro- 
scopic appearance and cultural characters, closely resembled 
E. albicans. Fourteen strains were identical and corre- 
sponded to E. tropicalis, whereas the other eight strains dif- 
fered from E. tropicalis, and from each other. The behavior 
of the different strains, especially toward sugar solutions, 
indicated that there are nine different species. Castellani 
believed that six of these species were parasitic, but he was 
not certain about the other three. It may be possible that a 
similar condition as to the plurality of species of Endomqyces 
affecting man also exists in the temperate zone. 
Before describing the better-known pathogenic yeast-like 
fungi, it may be well to consider first the development of the 
parasitic theory of cancer. This disease, more than any 
other human ailment, has been a fruitful field for the dis- 
covery of such forms as resemble yeasts. 
The one common characteristic of cancers is the power of 
cell proliferation, and the problem that many scientists to-day 
are undertaking is the causes underlying such proliferation. 
Many investigators take the view that cancer has some spe- 
cific and demonstrable cause. 
By the continued division of the carcinoma cells, masses 
of tissue are formed which grow out into lymph channels. 
Mechanically obstructing the normal activities of surround- 
