[Vor. 8 
296 ANNALS OF THE Missourt BOTANICAL GARDEN 
In close connection with the anatomical changes produced 
in the body a study should be made of the physiological 
relations of host and parasite, more particularly the con- 
ditions which predispose the body to attack. Sticker (’00) 
observed that mycosis in man may be of sporadic or of 
endemic origin. In the former case weakened individuals 
suffering from other diseases are attacked. Out of thirty- 
nine cases of mycosis only five occurred in persons sup- 
posedly in good health. The endemic disease appears in con- 
sequence of the patient’s vocation: for example, the pigeon 
caretaker, hair-dressers in Paris, and the sponge purifiers. 
The diseases produced by fungi, in proportion to the wide 
distribution of parasitic species, are of rare occurrence in 
man. Siebenmann, who investigated the distribution of As- 
pergillus fumigatus from the literature on otomycosis, dis- 
covered that, while it appeared in all parts of Europe and 
America, it was most abundant in India, its frequeney de- 
pending on the time of the year. 
The experimental results with injeetions of certain species 
of the Phycomycetes have been mostly negative. All au- 
thentie instanees of subeutaneous injections have given neg- 
ative results, whereas only a few species of the Phycomycetes 
produee death in animals by intraperitoneal or intravenous 
injeetions. "The resulting lesions in the rabbits and guinea- 
pigs vary with the manner of injeetion, the kidneys and 
mesenteric glands being regularly altered. An injection of 
a 2-ce. spore-suspension of a non-toxic fungus (Sterigmato- 
cystis mgra) will result in the animal’s losing 10 to 25 per 
cent in weight during the first three or four days after the 
injection; after this period the animal rapidly regains its 
original weight. If the amount of injection is increased, 
the animal will die from mechanical causes in about eight 
days. Sections of the kidneys show that the spores have 
collected in the glomeruli, where some of the spores ger- 
minate but no multiplication of cells takes place. The heart 
and blood remain sterile. 
Ballin (’08) subjected animals to five-day cultures of cer- 
tain moulds. He then killed the animals after a few hours 
