[Vor. 3 
300 ANNALS OF THE Missourt BOTANICAL GARDEN 
cells in certain organs, more particularly the kidneys, which 
resulted in the blocking of the glomeruli and mechanical 
injury of the tissues. Cases of eryptomycoses in man have 
been reported in large numbers and appear to be less rare 
than they were formerly supposed. 
Diseases of the skin are observed chiefly among persons 
living under conditions of uncleanliness, or among those who 
combine such conditions with a tendency to profuse perspira- 
tion. The disease does not penetrate into the skin itself, 
but consists, as Plaut has pointed out, of a simple sapro- 
phytism of the ineiting agent upon the skin. 
Certain species of Oospora and Sporotrichum which occur 
as skin parasites on man are non-pathogenie for other ani- 
mals. Quincke obtained negative results with the spores 
of Oospora ( Achorion) by subcutaneous, intraperitoneal, or 
intravenous injections into mice, rabbits, and dogs. Citron 
(^05) made intraperitoneal injections of 14-day growths of 
Oospora in beer-wort suspended in salt solution. Pseudo- 
tuberculosis of the peritoneum resulted from injections of 
either the living or the heat-sterilized fungus. 
The question whether or not there are any species among 
the many known yeasts which are pathogenic for man and 
animals has been the subject of observation for some time and 
has been answered mostly in the negative. All the animal 
experiments made with true yeasts found in nature have 
given negative results. Raum (91) and Neumayer (291), 
working on the pathogenicity of yeasts up to the year 1891, 
came to the conclusion that cultivated yeasts are non-in- 
jurious to animals. Raum used ten fungi, including Sac- 
charomyces cerevisiae, 8. Pastorianus, S. ellipsoideus, and 
S. turbidans. In only one ease of Neumayer's was an injuri- 
ous effect on animals manifested. Fischer and Brebeck (294) 
obtained negative results with ten species of Mycoderma, 
Monilia candida Hansen, and Torula salmonicolor. Rabin- 
owitsch (795), with fifty cultures of non-spore-forming yeasts, 
obtained evidence of an injurious action with seven of these 
fungi, but only in white rats, and in these cases it was neces- 
sary to use large quantities. San Felice has been able to 
