1897J MICROSCOPICAL JOURNAL. 279 



aestivo-auturanal types the spores are irregularly formed 

 or stellate, six to eight in number, possibly more, and 

 segmentation occurs chiefly in internal organs. 



Crescents and Flagella. — The crescents are found 

 only in the aestivo-autumnal forms, and represent a very 

 resistant form of the organism. They may exist for 

 months at a time without fever or other symptoms. They 

 may be converted into round bodies, from which flagella- 

 tion is frequently observed. We have not seen crescents 

 apart from extreme anemia. Persisting as they do we 

 can scarcely consider them solely as degenerate forms ; 

 they impress us rather as resting stages. Flagella may 

 be found in any type, though not frequently in quartan 

 fevers. They may be seen when quinine has been pre- 

 viously given, and have been considered by some as 

 degenerate forms. They are but rarely seen in freshly 

 shed blood, but we have seldom missed them when exam- 

 ining a specimen for a long period, e. g. in clinic demon- 

 strations. 



Individual Symptoms. — The diagnosis of individual or 

 isolated cases is most intimately linked with the diagno- 

 sis by blood examination. Certain malarial symptoms 

 are not only immediate sequences of the malaria] infec- 

 tion but are also most beautifully explained by the life 

 cycle, life activity and metabolism of the organism. 



The melanemia corresponds with the structural disin- 

 tegration of the hemoglobin of the red blood cells and its 

 diffusion through the blood plasma. The anemia is 

 secondary to reduction of the hemoglobin and diminution 

 of the number of red blood corpuscles; in other words, to 

 morphological hemodyscrasia. No leucocytosis is seen, 

 save a transient apparent increase at the beginning of 

 the paroxysm. The hemoglobin and red discs are des- 

 troyed in equal degree. The anemia is rapidly produced; 

 in fact, corpuscular deglobulization is more rapid than in 



