1897] MICROSCOPICAL JOURNAL 327 



or whether through the alterations it produces in the 

 different viscera, and especially in the liver — which, as is 

 well known, should be considered the organ of defense 

 against microbes — favors in the dog secondary infections 

 having their point of departure in the intestinal canal. 



This is an important point of resemblance between the 

 yellow fever of the dog and that of man. 



From the results of the first part of the investigations 

 relative solely to the comparative morphology, biology, 

 and pathology of the "bacillus icteroides," we can deduce 

 some fundamental conclusions concerning the etiology 

 and the pathology of the yellow fever of man. 



Yellow fever is, then, an infectious disease, due to an 

 organism well defined and susceptible of being cultivated 

 in the common artificial nutritive media. 



The micro-organism, which I have designated pro- 

 visionally with the name of "bacillus icteroides," can be 

 isolated, not only from the cadaver, but also during the 

 life of the yellow fever patient. 



Its isolation presents generally difficulties, sometimes 

 invincible, due in part to the constant presence of secon- 

 dary infections, and in part to the relative scarcity of the 

 organism in the body. 



These secondary infections, due almost always to cer- 

 tain species of microbes, as the coli bacillus, the strepto- 

 coccus, the staphylococcus, the proteus, etc., may appear 

 in tbe organism long before the death of the patient, 

 which is often attributable to their action rather than to 

 that of the "bacillus icteroides." — Med. Record. 



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