Notice of new Medical Preparations. 293 
oo T iNaias of new Medical Eitrigg tsi %y G. W. Cane 
PENTER—communicated by him 
1. Precipitated Extract of Bark. 
This extract contains quinine, cinchonine and the new organic al- 
kali chinioidine ; it possesses all the febrifuge iia of the quin- 
ine and can be afforded at about one third of the pric 
In consequence of a scarcity of Peruvian bark in our market for 
some time past, quinine has likewise become scarce and its price near- 
ly doubled. It is therefore highly important to the community, to ob- 
tain, at a’less expetise, a preparation of equal efficacy, The above 
extract will fully effect this object, and being the product of the 
same cinchona and containing, in addition to the quinine, other alka- 
lies of the same bark, of at least equal efficacy to that of the quinine, 
it may be expected that after being fully tried by the faculty it will 
be adopted by them. Chemists and pharmaceutists have long thought 
that cinchona contains other active alkaline principles in addition to 
those already discovered in the bark, and the conclusive facts i in re- 
lation to the use of quinine, of the entire bark and 
extract, sustain this opinion 5 3 for. many intermittents, which resisted 
numerous doses of six or eight grains of quinine, have yielded to the 
bark in substance. The late Dr. Emlen first used the residuary ex- 
tract of bark, after the extraction of the quinine, and found that in 
doses of two grains it was quite equal to the sulphate of quinine: 
and Drs. Parrish and Wood, distinguished physicians of this city, 
have fully confirmed Dr. Emlen’s experience.* 
Dr. Sertiirner, chemist, cf Hamelin, likewise confirmed what has 
been observed by others, that, as a tonic, quinine cannot be ‘substi- 
tuted for cinchona, and made analytical researches on the bark to 
discover the cause of the difference. The precipitate obtained “by 
treating the acidulous extract of cinchona by alkalies comprises, be- 
sides quinine and cinchonine, certain additional organic alkalies. 
These new organic alkalies, especially the principal one, which Dr, 
S. calls chinioidine, are intimately united with a sub-acid, resinous 
substance. The new alkali exists in the cinchona bark, associated 
with quinine and cinchonine, and they are all precipitated together 
in the above extract. The chinioidine resembles the other alkalies 
* See Journal of the Philadelphia College of Pharmacy, Vol. I, p. 44. 
Vou. XXII.—No. 2. 38 
