294 Notice of new Medical Preparations. 
of cinchona in its solubility, color and taste; but it is distinguished 
from them by its activity, its greater capacity of saturation, its alka- 
line reaction, and its intimate combination with an extractive matter. 
Dr. Sertiirner further states, that, as a medicine, chinioidine is one 
of the most precious agents of the materia medica. It is not only 
a better febrifuge than quinine, and even than the bark in substance, 
but it possesses many other therapeutic properties, which, admitting 
that they exist in the bark itself, are not to be found in quinine. It 
was prescribed by Dr. S. in the dose of two grains, three times a 
day. In all the cases, treated by the new remedy, the fever was 
cut short without relapse, and in every instance the concomitant 
symptoms, such as paleness of the face, loss of “appetite, @dema of 
the legs, &c. disappeared in a shorter time than is usually the case. 
The medicine failed only in a single instance. The quantity neces- 
sary for a cure was generally from twelve to twenty four grains.* 
The above extract is kept of two degrees of consistence; the soft 
can be made into pills with the addition of liquorice powder or starch, 
and the hard can be pulverized and made up with conserve of roses 
or syrup. It can be made into a solution in either state, with water, by 
the addition of one drop of sulphuric acid to each grain of the extract. 
The following formula is an elegant mode of exhibition which pies 
duces a beautiful transparent solution. 
R Precipitated extract of bark, - - 48 grains. 
cid sulph i - - - - - 40 drops. 
Alcohol, AS - - - 2 drachms- 
Aqua cinnamon, - - - - - 4 ounces. 
Drop the sulphuric acid in the alcohol with about two drachms of 
water, which should be used to triturate and dissolve the extract, 
after which the remaining water should be gradually added. If al- 
cohol is inconvenient it can be made without it, and common water 
can be substituted for the cinnamon. 
- Henry and Delondre of Paris differ in their opinion with 
Seniihids, and consider what he denominates chinioidine to be @ 
compound of quinine and cinchonine, associated with a peculiar yel- 
lowish substance of very difficult separation. I think the opinion of 
Sertiirner to be correct, as it is supported by numerous pharma- 
ceutical facts and characteristic properties of the substance. The 
peculiar yellowish substance of very difficult separation, described 
* See Journal des Progres for 1829, Vol. IIT. 
