THE HOKSE. 133 



blood, taken from a glandered horse, in dogs, produced the disease, 

 which would seem to indicate that in this way the blood was more 

 actively infectious than by intravenous injection." 



Chauveau looks upon the active principle of infection in the blood 

 as being based on certain suspended particles, leucocytes, or other 

 form-elements, and not upon the serum. 



Time failed me to make any search over the literature as to the 

 existence of the infectious principle in the secretions of the parotid 

 and other glands, or the urine, although Gerlach casually mentions 

 that the latter is infectious, without giving any experimental proofs. 



Both practical and experimental experience sufficiently prove the 

 fixedness of the infectious principle of glanders. 



AVe know that it is contained in the discharges from the nasal 

 cavities, in the secretions of the cutaneous ulcers, and that whatever 

 becomes polluted with such material, be it the harness, cribs, bed- 

 ding, or any other accidental vehicles, may retain its dangerous prop- 

 erties for a long time. 



A valuable experiment could be made as to infectiousness of the 

 faeces from horses diseased with glanders. 



Tenacity of the Contagium. 



The infectious principle of glanders retains its activity for a long 

 time, and under varying influences. "When a vehicle — nasal dis- 

 charge — is spread out, and quickly dried, on any hard substance, it 

 soon loses its activity, but in stables where it pollutes the crib, etc., 

 it retains it many months. It loses its activity on exposure to a 

 temperature of 45° R. ; by exposure to scalding water, or by the ac- 

 tion of chemical agents — disinfectants — such as chlorine, carbolic 

 acid, etc. — but only when brought into actual contact with the same. 



Decomposition does not appear to thoroughly destroy it (Ger- 

 lach). It seems to lose its virulence when introduced into the in- 

 testines (as flesh) of man, the dog, swine, and hens, but while not 

 so active, is still capable of causing infection in the horse. 



The dispersion of the infectious principle over the organism is 

 by means of the blood and lymphatic systems. 



The Entrance of the Infectious Principle into the Organism — that 



is, Natural Infection. 



Experience goes largely to prove that while the infectious ele- 

 ments of glanders have a fixed character, that is, are not capable of 

 being taken up by the atmospheric current, and carried to any great 

 distance from the point of original generation, or lodgment, still that, 



