118 



Psychotherapeutic Agents 



(Patent 5,138,062) 



Nicotine Analogues 



Dose (IP) 

 mg/kg 



Body Tranquilization 

 Sedation Tone (IVC) 50 ug 



R -(CH2)2- N^ 



CH3 



CH3 



10 

 20 



.= c/? 



NICOTINE : 



cy? 



++++ 



(Data from Rats) 



Chart M 



