300 



56 



"Aldehydes such as accetaldehyde, are toxic to cilia as Is hydrogen 

 cyanide (HCN), which also Interferes with respiration. A single 

 cigarette delivers 40 to 250 ug (symbol) of HCN. In rats a dose of 

 170 to 230 ug per kllograni of body weight causes unconsciousness and 

 590 to 640 ug per kilogram of body weight is lethal." ^^^ 



5. No Reduction ln Disease Risk 



New England Journal of Medicine : 



"...a recent study showed that t'le risk of myocardial infarction 

 increased with the number of cigarettes smoked but did not differ 

 between smokers of low-yield cigarettes and those of high-yield 

 cigarettes." '^^ 



Surgeon General ; 



"... the absorption of carbon monoxide Is more dependent on depth of 

 inhalation than 1s the absorption of nicotine and. If the use of 

 lower 'tar' products results in a compensatory increase In depth of 

 inhalation, smoker exposure to carbon monoxide may remain unchanged 

 or actually Increase. The reality of this concern Is borne out by 

 those studies that show no lowering of carboxyhemoglobin levels in 

 smokers who switch to lower 'tar' cigarettes. If carbon monoxide Is 

 an active etiologic agent for cigarette-related coronary heart 

 disease, and if significant compensatory changes in the style of 

 smoking occur with use of lower 'tar' cigarettes, then the risk of 

 coronary heart disease with lower 'tar' cigarettes may be similar 

 to, or possible greater than, the risk of smoking higher 'tar' 

 cigarettes." '^9 



"... the risk of developing emphysema may not be related to the 

 'tar* y1«1d of the cigarette smoked. Even If the reduction in 'tar' 

 results In a reduction in smoker exposure to 'tar,' a pattern of 

 coHpcnsatlon that produces a deeper inhalation may deliver a greater 

 dose of the gas phase of that smoke to the alveoli where it produces 

 a pathogenic effect. In addition, the techniques used in 

 formulation of the newer very low 'tar' cigarettes may result in an 

 Increase in the concentrations of etiologic agents in the smoke. 

 Therefore, the relative risk for lower 'tar' cigarette usage in the 

 development of chronic obstructive lung disease is highly 

 problematical." ^^° 



