333 



- 90 



The 1982 fUport of the Surgeon General also noted the pressing concerns 

 about the changing cigarette product and particularly the role of chemical 

 additives in the production of harmful constituents. 



The changes in flavor comoosltlon or changes In tobacco that 

 affect the "flavor bouquet" of tobacco products may conceivably 

 be responsible for mutagenic, tumorigenlc, or otherwise toxic 

 smoke constituents. Monitoring and identifying such biological 

 activity and associated chemical characteristics remain a 

 constant responsibility of the tobacco health reseotch 

 scientist. 



Evidence released at the Cipollone v. Liggett Group. Inc. . trial in 

 New Jersey indicates that as early as 1959 Philip Horrls had reason 

 to be concerned about additives, and other constituents. A 

 presentation made to the President's office of Philip Morris noted 

 that if the food and drug laws were ever applied to cigarettes 

 "certain constituents, like arsenic and other insecticides and 

 certain minor smoke constituents might have to be controlled.* A 

 1963 memo from Philip Morris' research director to a senior 

 executive indicated "We believe that the next medical attack on 

 cigarettes will be based on the cocarcinogen idea. With the 

 hundreds of compounds in smoke, this hypothesis will be hard to 

 contest,"; (b) that irritation problems from cigarette smoke "are 

 now receiving greater attention because of the general medical 

 belief that irritation leads to chronic bronchitis and emphysema. \ 

 Thtese are serious diseases involving millions of people. Emphysema 

 is often fatal either directly or through other respiratory 

 complications. A number of experts have predicted that the 



