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March 25, 1994 Page 9 



a prototype of Premier that was rated at 0.34 mg (106% 

 increase) .' 



People don't smoke like the machine. As detailed in the 

 1988 Surgeon General's Report (USDHHS, 1988), they generally take 

 larger puffs than 3 5 ml and do so in a shorter amount of time 

 than 2 seconds. Robinson, Pritchard and Davis of R. J. Reynolds 

 also found that smokers take larger puffs (mean 51 ml) (Robinson 

 et al, 1992) J 



Shorter, larger puffs, like those most smokers actually 

 take, move air at a higher velocity through the cigarette. This 

 may permit proximal parts of the cigarette to reach higher 

 temperatures than those reached under FTC test conditions. This 

 effect would be expected to release more volatile components such 

 as nicotine into the smoke. This, in turn, predicts that, puff 

 by puff, the smoke ingested by smokers who draw in air through 

 the cigarette at higher velocities than that used by the machine 

 will have higher concentrations of nicotine than those taken by 



" In all, three of 22 subjects in these two studies had 

 strikingly lower nicotine levels than the other 19. In 

 interpreting their data, both teams of investigators assumed that 

 a low nicotine level meant that the subject inhaled very little 

 smoke. The RJR team did not even include the two non- inhaling 

 subjects in its study in their final analyses. The RJR team was 

 only interested in the data from the ten subjects who inhaled. 



^ Their paper, "Psychopharmacological effects of smoking a 

 cigarette with typical "tar" and carbon monoxide yields but 

 minimal nicotine," is included as an attachment to this 

 statement . 



/ 



