404 



March 25, 1994 Page 16 



has happened in forty years . 



• Rather than discourage inhalation by product design and 

 by consumer warnings, the industry has conducted 

 elaborate animal studies of tobacco smoke inhalation. 

 For instance, the Council for Tobacco Research, through 

 its Special Projects operation, funded a $10 million 

 mouse study under a contract titled "Smoke inhalation 

 studies in mice." (Henry and Kouri, 1984; Colby, 1992) 



• William L. Dunn, Jr., of the Philip Morris Research 

 Center, speaking at a CORESTA-TCRC symposium in 1972, 

 repeatedly referred to the fact that smokers inhale and 

 consequently absorb nicotine. The thesis of his paper 

 is that absorption of nicotine produces effects that 

 the smoker has sought (Dunn, 1972) . 



• The R.J. Reynolds Tobacco Company treats inhalation as 

 a major feature of intended cigarette use. When the 

 company sought to show the scientific community how 

 cigarette-like Premier was, it did not publish taste 

 tests. Instead, it published a detailed study of the 

 pharmacokinetics of nicotine, comparing nicotine 

 absorption from a cigarette with that from prototypes 

 of Premier. (RJ .Reynolds Tobacco Company, 1988) 



• An Imperial Group Limited patent for a novel nicotine 

 delivery system notes, "Among the reasons why most 

 people smoke conventional cigarettes is that they wish 

 to inhale an aerosol containing nicotine." (Imperial 



