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March-257T.994 Page 2 3 



Tobacco Manufacturers Intend to Provide "Desired Physiological 

 Activity" 



In patent no. 3,584,630 (issued June 15, 1971), Philip 



Morris declares. 



It has long been known in the tobacco industry that in order 

 to provide a satisfying smoke, it is desirable to maintain 

 the nicotine content of tobacco products at a uniform level. 

 However, it is difficult to accomplish this result since the 

 nicotine content of tobacco varies widely, depending on the 

 type of tobacco and the conditions under which the tobacco 

 is grown. . . . 



Maintaining the nicotine content at a sufficiently high 

 level to provide the desired physiological activity, taste, 

 and odor which this material imparts to the smoke, without 

 raising the nicotine content to an undesirably high level, 

 can thus be seen to be a significant problem in the tobacco 

 art. The addition of nicotine to tobacco in such a way that 

 it remains inert and stable in the product and yet is 

 released in a controlled amount into the smoke aerosol when 

 the tobacco is pyrolyzed, is a result which is greatly 

 desirable . 



The present invention provides a solution to this 

 longstanding problem and results in accurate control of the 

 nicotine which is released in tobacco smoke. 



For Philip Morris, providing a satisfying smoke involves 

 controlling the nicotine delivery in a precise manner so that its 

 customers receive the "desired physiological activity, taste and 

 odor." The "physiological activity" of nicotine can only be 

 understood to mean some of its pharmacologic actions on the 

 brain. 



The term "physiology, " though, suggests the maintenance of 

 homeostasis, of a state of normalcy, in the body, in contrast to 

 the term "pharmacology, " which more suggests a change in the body 

 brought about by a drug. In individuals tolerant to the actions 



