506 



APPENDIX A 



CJwplcr 4 



Figure 1 



Nicotine absorption rales from tobacco smoke and smokeless tobacco 



20 r 



> % Cigaraltas 

 A"— A OralSniitl 

 ^y-—-a Chewing Tobacco 



^ ^ Nicotine Gum (4 mg) 



16 - n»10 





fO 



8 



c 

 o 

 O 



09 



c 

 o 



z 



CO 





_L 



_L 



-10 



30 



50 



Minutes 



90 



120 



Average blood nicotint levels in 10 nnen who siriokBri \r\f 9 Tiin (1.3 cigarettes), piacoi 

 2.5 g moist oral snuff In the mouth for 30 min. chewed an average of 7.9 g (range of 0.9 g 

 to 17 B g) chewing tobacco for 30 min. and chewed * mg niL-otine gum (two 2-mg pieces 

 of Nicorene) for 30 mm. SfwtJies were performed m the rr.orn:ng after overnight absti- 

 nence from tobacco. 



'Source Addpted from Benowin ei ai.. ^986 



'With I'SguIiir daily ci\;arettt .smnkin\:. blooil ot plasma levels ol nicouriv 

 sampled in the aflcinooii when those levels aic ai or ticar steady slate 

 generally range from 10 to 50 ng/mL. in a rtsearth ward study of eight 



22J 



