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PHILIP MORRIS U. S. A. 

 IHTCR-OFFICE C R « £ S P H £ N C E 



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Or. Jl. 1. Scllgaaa 



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J. L. Chsrlts 



oatK March 18, 1980 

 Wlcotln» R«c«ptoT PTogTMi ' PnlvTslty of Roch«5t»'T -. -^ ';''; 



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.,>r.\. Wlcotla* !• A pw«rful phar««colofic«l tftn't with ■•;;:. 



,Bultipl« sitas of action asd aay b« th« aost ispoftant .,: -'^c-. 

 essBonant of cicaratt* ssoka.' Nlcotlao and aa vuidarstanding 



*of Its proptrtlas art laportaat to th» eontlnuad wall •--* 

 baing of OUT cigarstt« businass slnca this alkaloid has" baan 

 eitad oftaa as "tha raaioa .'or saokiag*' aad thaorlas hava 

 ba«a advaaead for "aicotiaa titration" b/ tha saokar. Nicotin 



^is kaowa to hava affects oa tha cantral aad paripharal aarvous 



"systta as wall, as iafluaacing maaory, loaming, paia parcaptioi 

 rasponsa to strass aad laval of arousal. 



.• -..- I- 



■^r-'TT.: It is not suprising that a compound with such a aultituda 

 of affects would hava properties which are considered ~' .'^;^ • 

 undesirable by tha anti- sacking forces. Claias ar« aada 

 that nicotine in cigarette saoke can induce chest pain and 

 irregularities ia cardiac rhytha when a person witA a cosproai: 

 cardiovascular systea saokas or when parsons with cardiac 

 disease are exposed to high concentratioas of sid* streaa saoki 



- **■• ^*^ 



■' ■ For thasa reasons our ability to ascertain th« structural 

 features of tha nicotine aolacula which are respoaalble for 

 its various pharaacologieal properties can lead to tha design 

 of coapouads with eahaneed desirable properties (eaatral . . / 

 nervcuj systea effects) aad ainiaized suspect pro^rties 

 Cperl.^theral nervous systea effects). There are aany opportunit 

 for acquiriag proprietary cospounds which can serve as a fira 

 fouadatioa for.aew aad iaaovacive products ia the future. 



. Tlic above is aa excerpt froe an introduction to the nieotl 

 prograa which I wrote on 12/1/78. My views have not signiflcar 

 changed siaee that tiae. I believe that nicotine does play an 

 iapertaat role in the sacking process. How iaporcant that role 

 is reaaias to be determined. The receptor program at the 

 University of Rochester is an integral part of the aicotine 

 prograa and can be justified in a number of ways. Aa initial 

 thought was that Or. Abood would have the knowledge and techniq 

 to perfora screening of nicotine analogs for CNS activity. 

 The synthesis group has created a nuaber of interesting compoun 

 which are now being screened by Dr. Abood. In addition 

 Dr. Abood was to carry out fundaaancal studies on sites and 

 mechanisms of action of nicotine in the brain. That research . 



is in progress. 



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