686 



PHILIP MORRIS 



USA. 

 1?D PARK AVENUE, NEW YOHK. NY 10017 



William I. Campbell 



POtSIOCNT »NC5 

 CMICr CXCCUTIVE OrriCEH 



AprU 26, 1994 



Henry A. Waxman 

 Chairman, Subcommittee on Health 

 and the Environment 

 2415 Rayburn House Office Building 

 Washington, DC 20515-6118 



Dear Mr. Chairman: 



I have had an opportunity to review an unofficial trar^crlpt of the April 14 

 Hearing. While I may have additional clarifications for the Record after further 

 review, there are a few clarifications I would like to make now. 



Congressman Synar, in referring to Dr. DeNoble's impublished 1983 

 manuscript, said that the research described in the manuscript "found that rats 

 will self-administer nicotine when hooked up to an intravenous nicotine 

 solution." Congressman Synar went on to say that Philip Morris's March 31 

 press release "said the DeNoble study showed exactly the opposite." I don't 

 believe Congressman Synar is correct. The Philip Morris press release said that 

 Dr. De Noble "conducted nicotine-related research and concluded that nicotine is 

 a reinforcer in the class of non-addictive chemical compounds such as saccharin, 

 or water ...." And that is indeed what he concluded. The press release went on 

 to say that Dr. DeNoble "did not believe nicotine fit the accepted criteria for drug 

 deperuience." And again, that is indeed what he concluded. Our press release 

 did not say that Dr. DeNoble's 1983 unpublished manuscript showed anything 

 Other than what it did. 



Congressman Synar asked me whether Dr. DeNoble's work was part of 

 the Company's "effort to develop a nicotine analog, which are chemicals which 

 would have addicting or reinforcing features without any [of some] sic of the 

 nicotine side effects? Yes or no?" In answering "yes," I was not agreeing that 

 either nicotine or the analogs had addicting features, but simply that the analogs 

 might be reinforcing. 



