784 



320 



GORJ AND LYNCH 



HtcoOnt Mate 

 mgAift Day 



Fig. 4. Nicotine intake per cigaretle and daily nicotine intake per kilogram of body weight Mean trends 

 as a function of FTC nicotine yield. The straight line teprescnts expected values if mean intakes per cigarette 

 *ere equivalent to FTC nicotine yields (95* confidence intervals). 



Cigarette Consumption 



Figure 5 indicates that mean daily cigarette consumption is not significantly affected 

 by FTC nicotine yield for the sample of thb study. Similarly, Fig. 6 indicates that 

 mean plasma nicotine levels are poorly related to the number of cigarettes smoked 

 daily, probably reflecting the absence of smokers of less than 10 cigarenes per day in 

 our sample. For those smokers the relationship is likely to be more pronounced, as 

 the beginning of the curve in Fig. 6 suggests. 



Expired CO 



'^igure 7 shows virtually no correlauon between FTC CO yields and expired air CO 

 values. The correlation of expired CO and plasma cotinine and nicotine \*-as negligible 

 even after correcting for FTC nicotinc/CO ratios of the brands smoked (Y = 26.8 

 + 1 .3A', r = Q.[5,P< 0.00 1 ), suggesting strong interference from environmental sources 

 of CO inuke, other than cigarettes. 



DISCUSSION 



Sicotine ar\d CO Intake 



The results show that in a sample of smokers representative of the entire market, 

 mean cigarette consumption is unaffected by the FTC nicotine yield (Fig. 5) and that 



