824 



INTERNATIONAL SYMPOSIUM ON NICOTINE 

 The Effects of Nicotine on Biological Systems II 



Salcllite Symposium of (he XKth In(eniii(ianiil Congrcis of I^armMolog)' 

 Montreal, Canada July 21-24, 1994 



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INTER-INDIVIDUAL VARIATION OF NICOTINE UPTAKE AMONG SMOKERS 



G. D. Bvfd J. H, RobinsoQ. W. S. Caldwell, and D. J. deBethizv. R I. Reynolds Tobacco Company, 



Product Evaluation Group, Winstoa-Salem, .NC 27102. 



Cigarette amokere have a wide variety of "tar" and nicotine yidd pKxiuds to choose ftom in the 

 current market, rwiging from 0.5 mg 'tar" aad less than 0.05 mg oicotioe to 27 mg "tar" and 1.8 mg 

 nicotine by FTC method. To better undcrstaad the rektionahip between FTC nicotine yields and actual 

 nicotine uptake in smokers, we have studied nicotine uptake in 33 smokers that spanned four groups: 1 

 mg "tar" (IMG), ultra-low "tar" (ULT). full-flavor low "tar" (FPLT), and full fkvor (FF) cigarette 

 smokers. These cigarette categories had mean FTC nicotine yields of O.U. 0.49, 0,67 and 1.13 

 mg/ctgareac, respectively. The subjects smoked ad libitum their usual brand of cigarette and submittol 

 a 24 h urine sample for total nicotine upta.ke analysis over a period where the number of cigarettes 

 smoked was racorded. Nicotbe uptake was determined by monitonng urinary nicotine and its 

 metabolites, including the glucuronide conjugates. Daily nicotine uptake was 9 I ± 7 J mg (range 1-21 

 mg) for IMG, 19.2 ± lO.O mg (range 4-42 mg) for ULT, 21.8 ± 9.4 mg (range 13-38 mg) for FFLT, 

 and 37. 1 ± H.4 mg (range 21-60 mg) far FF smokers; on a per cigarette basis this equated to 0.23 i 

 0.11, 0.56 ± 0.23, 0.60 i 0.18, and 1.19 ± 0.43 mg nicotine, respectively. .Mthough the number of 

 subjects in each group is limited, tneana for the different groups showed that lower FTC yield 

 cigarettes result in not only leaa nicotine uf)take per 24 h period, but aUo per cig&rette smoked. These 

 data .suuucst that nicotine uptake is a function of individual smoking behavior within product design 

 limits. We conclude from these data that, while FTC yield cannot prfcciscly predict nicotine uptake for 

 an mdividuai smoker, it is useful in predicting and comparing actual nicotine uptake by smolccrs who 

 select cigareliM with a particulai' FTC yield 



