835 



ATTACHMENT 1 (continued) 



a«n«ral caiaraotcristiot* 

 of 13 Von-SAFU8 Cigar^tt* XB9r«4ienks Ixom the 1992 liat 



40596-$9>8 



MttiibeprMi* la a liquid anU Is acutely nontoxic to rodents via the 

 oral or Inhalation routes of exposure but It moderately toxic to 

 dogs. It Is nonirrltatlng to ocular and dermal tissues of exposed 

 animals. Kethoprene was also devoid of adverse toxio endpolnts 

 when tested in oral and inhalation aubchronic studies as well as In 

 a teratology and a three-generation reproduction study in rate. No 

 chronic or carcinogenicity toxicity data were found in literature 

 reviewed . 



64961-66-0 



Tobacco leaf aqpieous extract, a residue of a methylene chloride 

 extraction dissolved in dimethylsulf oxide, was consumed by pregnant 

 sows during the first trimester. The sows appeared unaffected by 

 treatment. Arthrogryponis, a persistant joint curvature, waa 

 induced in their offspring, thereby confirming the teratogenic 

 nature of tobacco leaf extract. None of the deformed offspring 

 were able to stand. The specific teratogenio agent in the extract 

 was not identified. A carcinogenicity study was performed in rats 

 that received tobaooo leaf extract dally for 21 months. The 

 treated animals developed lung adenooas (10%) and gastric 

 papillomas (101) while an equal number of controls were devoid of 

 these tumor types. 



112-58-3 



Di-B-hexj^l ether is a nontoxic liquid via the oral route of 

 administration and is poorly absorbed through the slcin. Animals 

 exposed for eight hours to saturated vapors did not die. It is 

 also a mild to moderate irritant to contacted tissues. No 

 reproductive, developmental, subcbronlc, chronic, or 

 carcinogenioity toxicity data were found in searched data base*. 



459-80-3 



Oeraaie aeid is a nodarafcoly texie iiepald whon in^eeted and of 

 lower toxic potential via the dermal route of exposure. It is only 

 moderately irritating when applied full strencth to abraded skin. 

 Exposed human volunteers did not develop sensitization reactions 

 when challenged with this compound. No reproductive, 

 developmental, subchronic, chronic, or carcinogenicity toxicity 

 data were found in the reviewed literature. 



•KOTB: 



That* iubitanoei vera Idantlfled by oowparing tha in^zediantt addad during tha 

 i»anufMtur« o< eigaratta*, 4a •uhmlttad by tha oi«»rett* eoa^^niM in 1992, wtth 

 thota ingradiant* «ppa«ring on tha yOA't lift of approvad food additivaBi 

 •Bvarythlag Added to Food in the United Statei . " »ec«uBe the cigarette 

 ingredient li«t« do not provide Information on the quantity of in^radientB par 

 oigaratta, the following infomwtion describee general characteristics of the 

 substances . 



