15 



- e - 



PATENTS: 



Jirkovsky. I., King, G., Reinhart. B. and DeNoble, V. J. 6, 7. 8, 9-letrahydro-10. 

 methyl-pyrldo {1,2-Al indol-Q-aminet and derivatives ther*ot, useful fof tha 

 treatmani of cognitive impairmenti. US Patent 4,624,954-11-25-86, 1986. 



De^kJb^e, V. J.. DeNoble, K. F., Earl, R. A. Use ot serotonin-two type receptor 



antagofiiats in combination with neurotransmitter release enhancers (e.g. DtiP 096) 

 for treating cognition dyafunction. Caaa No. BP-6450, 1990. 



Chiu. A., DeNoble, V., Duncia, J.. Wong. P. Treatment of central nervoua eyetom 

 diaofderi with imidazole angiotdnajn-ll receptor antagonists. Case No. BP-643S, 

 1990. 



Chiu, A.. DeNoble, V., Duncia, J,. Wong. P. Treatment of central nervous system . 

 disorders with t>eruimida2ole angtotensin-il receptor antagonists. Case No. 

 BP-6456, 1990. 



Chiu, A.. DeNoble, V., Duncia, J.. Wong, P. Treatment of central nervous system 

 disorders with pyrazole, pyrrole and triazole angiotensin-ll receptor 

 antagonisU. Case No. BP-6457, 1990. 



Chiu, A.. DeNoble, V„ Duncia, J.. Wong, P. Treatment of central nervous 

 disorders with imidazole compound*. Case No. BP-6458, 1990. 



Johnson, A., Christos. T.. Schmidt, W.. Pottorf, R., Smyser, T., DeNoble. V., 

 Stewart, J., Gilligan, P., Cain, G., Maduskuie, T., Arvanitis, A. Panlally 

 pnstected C-terminal neurotervsin fragments and bond modified fragments as 

 analgesics. Case No. 6P-6S43, iQdO. 



Boswell, G. A., DeNoble, V. J. 6icyclo[2:2:2}oct-l-y1 amines as therapeutic agents 

 to treat cognibon dysfunction and Parkinsonism. Case No. BP-6515, 1991. 



DeNoble, V. J. The use of neurotransmitter release enhancers (eg DuP 921) in 

 combination with monoamine oxidase B inhibitors for treating cognitive 

 dysfunction. MOf submitted, 1991. 



Earl, R. A., DeNoble, V.J. 4.4'-(9H-f1uoren-9-ylidenebis (methylene)) 



•bispyrimidine for treating neurological disorders. Case No. BP-6444. 1992. 



