126 



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libit^ 



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43 



PHIUP MCRRIS U. S. A. 



I mn-oFf I cc com espoNoeNC £ 



neiiii««». Tiiiiiit 



Or. R. I. Sclifama 



-C0NFID£3^T 



J. I. Charlas 



il>lC<x -irt .V,' ^uo. 



ottM March 18, 1980 

 . ■ • -y.-... til .1 ■■ . ; •.•.* 1 

 ■ .'-.- ,.»;..-;•. . .—ijc-i ... . 

 . ;..;X^j- •!."(.'. :-.ik,---i«u-.irAijr. 

 Nleotig* Rtcaptor Prorrf - Unlvrtlty of Boch»«'t>r" '- • i*^: "1; 



. Mi:* '•• •'••-I '..;,■•-'• ••*- -■^■.•— •«» . -i^ «, »^ .; ^., . *^~3'.^ •^^. _ 

 ,-r^- Hlcotia* Is a powarful pharmacolofictl aivnt wttk -. ." 

 .BUltipl* sic*s of action aad «*r b« tha aott {■poftant .:'- „■ 

 CMBoaaat of dfarattt smoU. Klcotlaa aad aa undaritandinf 

 of itj proptrtlas ara laportaat to tha continuad wall--' 

 balnt of OUT cijarttt* bujlnass slnca this alkaloid hai* baaa 

 cltad oftaa as "tha rtasea for laoklai" aad thaorlaa hAV 

 booa advaacad for "aicotlaa titratioa" by tha laokar.' Nlcotln. 

 _ij kaowa to hava affects oa tha cantral aad paripharaX aarvous 

 systaa as wall, as iafluaaciaf aaaorr, loamiag, pala parcaptioi 

 respoasa to strass aad laval of arousal. - -•-.— '-r.. :• . 



-''-'"-' It is aot suprisiaf that a coapouad with such 'a aultitua* 

 of af facts would hava propartias which ara considarad - -jt.^ ■ 

 undasiribla by tha anti-iaoking forcas. Claias ar« aad* ' • 

 that Bicotino ia cigaratto saoka can iaduea chast paia aad 

 irrafularltias ia cardiac rhytha whan a parson vltA a eoaproaii 

 cardiovascular systaa saokas or whan parsoas with cardiac 

 disaasa ara axposad to high concaatratioas of sid* strata saoki 

 . . '. ■ . . -- <«y ••••• .^-... • •. _. -.^^.-j •••5...-,; 



' For thas* raasons our ability to ascartaia tha structural 



faaturas of tha alcotia* aolacul* which ara raspoasibls for 

 its various pharaacologieal propartias caa laad to tha dasign 

 of coapouads with anhaacad dasirabla propartias (caatral ;. 

 norraus systaa affacts) aad aiaiaizad suspact prep«rtias ' -^ ' 

 (paripharal narvous rystaa affacts). Thara ara aaay opportunit 

 ^for acquiriag propriatary coapouads which caa sarv* as a fira 

 fouadatioa for. saw aad iaaovativo products ia tha fatura. --^ 

 ,.: :: j-y^'r-*:-\::-:: ■. • -.■ 



. Tha abova is aa axcarpt froa an introduction to tha aicoti 

 prograa which I wrota oa 12/1/78. My views hava net significas 

 ehangad siaca that tiaa. I baliava that aicotin* doas play an 

 iaportaat rola ia tha saoking process. How iaporcaat that rola 

 is reaalas to b* determined. Tha receptor program at tha 

 University of Rochester is an integral part of tha aieotir.a 

 prograa and can ba justified in a nuabar of ways. Aa initial 

 thought was that Dr. Abood would hava tha kaowledg* and tachniq 

 to perfora screening of nicotine analogs for G4S activity. 

 Tha synthesis group has created a nuabar of iatarasting conpoun 

 which are now being screened by Or. Abood. Ia addition 

 Or. Abood was to carry out fundaaoneal studies on sites and 

 aachanisas of action of nicotine in tha brain. That research 

 is in progress. Z^^ } j:'..^ ^^oama ■■ 





