526 



uNr."ERsrnr of California, san ftuncisco 



■ --JS r'" 



•TKoek or vr^es«t 



»fcT4 i««««4a ■ fc*x"» r».- 



Dlr«et: (4U) 6««-l7U 



S«etiea of H« 

 July 20, 1972 



icsls(7 tad IsBuaeldfj 



Hr. Sdvln .'aeeb 



Laucartctla 4 Liuctrsttla 



Oai leclt*l*lltt Pliu 

 Htv York, Mcv York iS020 



Dear Mr. Jacob: 



CONflDEHTIAL 



A« par your rtquatc, *r.elesad la aa eueliaa of ch« radeaala rt: 

 (cudy for liU4|a of cartcla Z» (aaecypaa co chreale ebacruetiv* 

 dlsaaaa, atpaelally, taphyitaa. I did te:« o( ehlj racldttala 

 pr«vlou.4]Ti hewavar, wi:h tha appaaraeea ot cha daca chae cha 

 alphai-aosltryptia (i=eeypaa aca Xiaxad to tha Ca lanecypa leeua 

 aakaa rvaa aora aaaja. 



To acar: t.haaa studlat, I :Mak li would ba bar.afldal Co hava Dr. 

 Joha Vivlae waUs as cha ?rlael.;al lavaadtacor, aiaea ha vat tb« first 

 CO daaeastrata chac a |lvaa Ca |aaoeyp« vat llakad co halghc of l^nia* 

 rasponsa co any anti{ta la aaa. ( Ua fava you a raprlac ea chl»; hevavar 

 la Cha avaac you hava alsplacad It. Cha raforaata It: J. V. Walls, 

 B. R. Fudaabari aad I. K. Maekty: Xaltdoa co cha husta aaclbedy 

 raspenta to flaiallla co C« Caaot/pat. J. :=su-ol .. ^:130J-13U, 1971.) 

 K* you knov, toaaalpha^-aaclcrypala tanoeypat v.tich ara rara art aet 

 aateclacad vi:h raduccisa oi acclvlty of tha alphax-aacicrypsla. Thus, 

 Cha oecunaaca e( asphysaaa la chat* paclaact al(hc aaraly radaet tha 

 fact Chat ll.ikata of tMa loeuj to thlt leeut to cha Ca loeut rtchar 

 chta cha face chtt tha PI* hoaetyfotat ara proaa to aaphytaaa. 



Aaethar raaaoa for hava Or. Ualla partlelpata la cMt srudy It that h« 

 hat jutt dltcevarad tha flrtt buaaa (teatle aarkar for :|.H, (J.V. Wallt, 

 J.T. Blausart aad V. H. Fudaabarg: Ruaaa Aatl-I^.M Iso-Aatibodlaa la 

 Subjaect wich Salaedva I(A Daflelaaey. Clin, c^e. Iraueol .. la arasa ). 

 aad It It eoaealvabla that li COPO or taphysasa aleca i* eua co aa laictal 

 iBJult by a vlrut or othar or|tnlt« to which tha aatlbody ratpeata It It.1, 

 cha laaa data al{hc hold eruo chara. l.a. cha llakaia it dua to ItH 

 gaaetyr* rac^ar chta I(C. 



PLAINTIPF-S 

 EXHIBIT 



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