549 



UNrVTRSITY OF CALIFORN'lA, SAN FRANCISCO 



<^r^T 



•ewcn • t^'ti • 0>'>T»< ■ uffl 





•cRook or >rTBie<* 

 DUAjimx.vT or ttBiat 



S«ctlsa of Hs 

 July 20, 1972 



Dlrtct: (*LS) 666-17U 



icelet7 «^ Xa8uool0(7 



Kr. Edvla Jacob 



laucarscola i Lauttrsttls 

 Ooa Xockaftlltr Plau 

 H«w York, Nav York 1C020 



Oaar >ir. Jacob: 



CONFIDENTIAL 



Aa par your raquaae, aneloiad Is ao oucllna of ch« raeloaala rt: 

 trudy for liixaga of ear^sin Ca (aaotypaa eo chroale obacrueclv* , 

 dlsaaaa, aapaelally, aophytaaa. I did sosa of chU rational* 

 praviou.«Jvi howavar, with cha appaarasca of cha dau chat tha 

 alphai-iocitrypsln t*=ocypaa ara liakad to tha Ca (anetypa locus 

 BAkas avaa aoia aaasa. 



To star: chasa atudlas, I thlak i: would ba baeafidal to hava Dr. 

 Joha Vivlaa Walls as cha 'rlacipal Iavasci|ator, ilaca ha was cha firsc 

 CO daooascrata thac a glvaa Ca (aaotypa waa Uajtad to haight of l^uaa 

 rasponsa co any ancigan la saa. ( Ua gava you a raprlae oa chl»; hovavar 

 la cha avaat you hsva adsplacad ic, tha rtfaraa:a Is: J. V. Walls, 

 B. R. Fudacbarg aad I. R. Maekay: Salatloo to tha Husan antibody 

 rasponsa to flagallla to Cm Casot/pas. J. :=;ur.ol ., _i07 :liOJ-lJU, 1971.) 

 As you knov, sosaalphd^-aatltrypsla ganocypas w.tich ara rara ara cot 

 assoelacad with raduetloa of activity of tha a:?ha;-a.iei:rypsla. Thus, 

 tha oeeurraaca of aaphysama la chasa paclaats alghc aaraly raflact tha 

 fact that li.::J(aga of tMs locus to this locus to tha Ca locus rathar 

 thaa tha fact that tha ?1* honotygotas ara prona to aaphysaaa. 



Aaothar raason for hava Dr. Walls partielpata la cMs study is that ha 



has Just diseovarad th« first human gacatlc aarkar for Ig.-<,(J.V. Walls, 

 J.r. Blauaars aad H. H. Fudaabarg: Huaao Aati-IgM Iso-Aacibodlas la 

 Subjacts with Salaetlv* IgA Daflclaacy. Clin. «.re. Irsucol .. in srass ). 

 aad It is coBcaivabls. that li COFO or aaphysaaa aloca is sua to aa iaitlal 

 Insult by a virus or ethar organlsa to which tha antibody raapoasa is I(.1, 

 tha aaaa data aight held trua thara, l.a. tha liakaga is dua to ItM 

 gaaetypa rat^ax thaa IgC. 



PLAINTIFF'S 

 EXHIBIT 



au f^*^ ^>a» m^» 30 





•.tir.utd 



