575 



342 FALSE AND MISLE^DEN'G ADVERTISENG '*'' 



3. Smoking and other tobacco habits, and the emotional and phvsical mat 

 ot smokers, with respect to establishment, duration, and mtensity of lobfl ** 

 use. and correlation "f these data with metabolic, glandular, and nervous tr2? 

 under various desrree* '■>t stress and '-hallense. '^T** 



m 



It is recognized that work has been done and is being done here and abm a 

 these fleids. The Scientific Advisory Boar<l plans to avoid repeatine wo^ 



? work 



that has produced accepted results, as in the field of the constituents of toba«^ 

 Where results have been inconclusive, however, considerable further car^S?; 

 study and well-planned research is Indicated. "renu 



C 



The progra m takes s hape 



In itstjecond~step>5he Board developed a coordinated research program in, 

 3(le d not only lb a-certain facts with respect to the questions raTSwrWmcere 

 ingTo Bgrro use and Bgdlth TT Tir nls^ t o ponrri hnfp t /\ r nrrh^r 'ihflcrjtafliUi nJ 

 ol cancer] heaiLL-di>''.i>'^ ><nd other public^eaTth oroblpms ~TK^~7;r7raTniff-T^- 



tinte nded to proiluce. clinical and e rperimeotal tlndln^ nece??JTy ~g vfurB ▼ ■[](« 

 co nclusions ca n he maile re^'Ml'dliii; | i u33ible let aTtuTgSTps becwe eu toPAcpo nf T- 



' ^ nd human heal th^ — -^ 



Among research projects being sponsored is the study of human lung cancer 

 in several major medical centers In the United States. A uniform method of 

 study will allow for a comparison of the frequency and types of lung cancer in 



'the geographic areas investigated. Such related factors as length of residence, 

 occupational histor.v, personal habits and associated diseases will be reviewed 



I for possible relation to the causes and onset of lung cancer. It is expected that 

 this research will furnish clues for still further research to be supported by th* 



■Committee. 



Research projects 



Research projects, to be supporte<l at sites to be selected, will be encouraged 

 in the following general subjects ( primary responsibility for overall advice and 

 informal guidance has been assigned to Individual Board members, as in- 

 dicated In parentheses » : 



Inhalation of smoker. — Carefully planned and regulated experiments will be 

 conducted with mammals subjected to inhalation of tobacco smoke under con- 

 trolled conditions. (Dr. Kotin.) 



Direct application of smoke tars. — Projects will test the effect of tdentifled 

 smoke tars, derived under controlled conditions, on tissues of animals with vary- 

 ing degrees of susceptibility to cancer or other ailments. ( Dr. Relmann. ) 



Study of lung tissues. — Projects to study lung tissues in living animals and 

 man will be undertaken. ( Dr. Reinhoflf. Dr. Lynch, and Dr. Reimann.) 



ilaiionant changes in tissues. — Studies of malignant changes of tissues will 

 be made under laboratory condition. ( Dr. Jacobson. ) 



Stuily of cardiovascular tissues. — Studies will be made of changes involvinf 

 degeneration or unbalance in cardiovascular tissues. ( Dr. Comroe. ) 



Habits and characteristics of smokers. — A series of surve.vs of selected popu- 

 lations in various parts of the country will be undertaken concerning the chkr- 

 acteristics of human smokers and nonsmokers. including age. sex. emotional 

 habits, environmental factors, and exposure, as well as smoking habits. (Dr.° ■ 

 Wilson. I " ■• 1 



Preparation and analysis of tobacco derivatives. — Sources will be developed 

 for a continuous supply of tars from tobacco smoke and its derivatives that cin 

 be used In various experiments. Efforts will be made to duplicate human sm(*- 

 ing in machines. Production of the derivatives will be regulate<l .«o as to ha*« 

 full knowledge of the conditions under which smoking is simulated. (Dr- 

 Cattell. ) i 



Initial research grants under the approved program went to scientists at sndi 

 institutions as the University of Southern California, the University of Texas, 

 the Temple University School of Pharmacy. Mount Zlon Hospital flt San Fran- 

 cisco, the Medical College of Virginia. Fordliam University. Harv.ird UniTer- 

 sity, Roswell Park Memorial Institute at Buffalo. New York University-Bellerue 

 Medical Center. Tufts College Me<lical School. University of Pennsylvania D«-: 

 partment of Surgery, the Medical College of South Carolina, and the College of 

 Physicians and Surgeons at Columbia University. 



Many new research projects are being considered continually hy tlie SclentlflP 

 Advisory Board, and approval of grants are announced from time to time. ^ 



1 



