26 



Federal Food, Drug, and Cosmetic Act. And Brown & Williamson is 

 not the only company that apparently has been involved in 

 research on nicotine's physiologic and pharmacologic effects. 

 Thanks to this Subcommittee's work, we now know that Philip 

 Morris was conducting nicotine addiction research. We are also 

 aware of research utilizing electroencephalographic measurements 

 to monitor the biological effects of nicotine on brain function 



27 26 20 30 31 



at both R.J. Reynolds and Philip Morris. 



Major projects undertaken by at least two companies to 

 develop cigarette alternatives also demonstrate that the industry 

 understands that nicotine is the critical ingredient they are 

 delivering to smokers. 



It is widely known that in the late 1980 's R.J. Reynolds 

 Corporation developed and test marketed a cigarette alternative 

 called Premier. It was smokeless and virtually tobacco free. It 

 was essentially a nicotine delivery system. To make sure that 

 Premier would be an acceptable alternative to smokers, R.J. 

 Reynolds conducted human studies to determine whether the 

 nicotine from Premier and from a standard cigarette was absorbed 

 into the blood of research subjects, metabolized, and excreted at 

 the same rate. 



Recent reports in the media reveal that Brown & Williamson, 

 too, launched an effort to develop a cigarette alternative. It 

 was referred to as "Ariel." Brown & Williamson's own documents 

 reportedly refer to Ariel as "a nicotine delivery device." One 

 of the applicant? for the patent for Ariel was Charles Ellis of 

 British American Tobacco, Brown & Williamson's corporate parent. 

 Ariel was composed of two parts: a source of nicotine and 

 aerosol, and a heating material such as tobacco that served to 

 heat the nicotine and cause the release of the nicotine and the 

 aerosol. 



Mr. Chairman, we further believe that recent reports in the 

 media also may be relevant to the determination of whether 

 nicotine-containing cigarettes are drugs. 



Let me quote some of the recently reported statements of 



