283 



- 2 



•oker Intenctjofl 





r- 



'v<-. 



17\ese'^HMll«s win continue as planned. They vlll b« extended to 



Include^l^^les of aniaal studies to detemtne the distribution 

 of up^r 7^V<tor/ tract nerve reflexes. Thejr will also be ased 

 to chaf^ternib the profile chealcals capable of eliciting nerve 

 responseC^Wtiert possible, there will be parallel hu«*n studies to 

 validate n(%-.anf*i1 findings In relation to subjective assessment. 



(b) Product dlfferOces," In teras of particle size distributions, have 

 been 1dent1f1ed^nd^t>i« tignlflcance of this for subjective product 

 assessment Is be1r<§>deter«1fted. Joint work with the Saoke Research 

 Group win attempt i^,dettr«1ne the relationship between particle 

 size, numbers and subfeytlve assessment. However, product Improve- 

 ment through aerosol nodti^catlon Is llclted by available resources. 

 The experimental c1g«rettev«ed In 1(b) will also be used to Improve 

 the efficient use of smoke >dtot1ne thr-O uq h pH modification . These 

 "-/y Studies wiTi «.^/»«nfi> »h* r»>itMnn«h*P between— MCQtlne do se-und 

 /. n1cot1ne-relatid-*ubjectijrft_im£355nei^. This will further help to 

 ^^iBFritTty the relationship b€tween'.:]^od(JCt acceptability and smoker 

 '^^tlsfactlon. ^X . 



U) No'^eclflc changes are planned other t»Mn diewltplng aore tangible 

 Hn'^s^^tween In-house research and cllfo^l '«Mles in terw of 

 ci^M>d1f1cat1on and consutser response. O 



3. sialtr^af 



(«) 



irno^plogy 



The wort^ll 'ftJMI 

 action w""" * ■■ '^' 



nue to Ident tlY-th e Mechanisms of nice 

 •»"»rffl fi'"'''""^ *y^tJ*- It will be ex! 



and changing brain concentrat1< 

 sslon tomograpny technlg uesT 



The human nicotine pha'^ co-kinetic study Is progressing welt» 

 although sample anal^^ t9^ the rate-limiting step. Within this 



-Inmiie assay techniques will be evaluated 



(. 



e^ftgrTJ^' 



context, alternative 

 •nd implemented where 



The human studies at the V.O.S. finical 

 win be extended to establish tite 

 that can prov ide Pharmacol oqicll 

 snrttirvrn-5e part of 1(H) and t(b)) 



Pharmacology Department 



ke nicotine 



smoker (these 



be •<fiJi"!«_^«i|LJ*>l 

 •at fiction fartT^e sa 



(b) 



(c) 



Ho specific mojiflcatlonj 

 research prograxne. 



o. 



» planned for th Ajq enol oharwacolool ctl 



/ 



The salivary studies irt proceeding as planned, H^ver, within the 

 programme of research, t he relationship be tween smate. oualltv -and 

 tillvatlon win be Inc luded. Where sultaBly tensltfverpethods are 

 developed, these will be made available to operating cavanles as a 

 means of Improving specific product attributes. 



(d) Ho modifications. 



c 

 hi 

 I 



o 



M 



O 



