311 



&ritlsh-la*rle*a T«btec« Co. 1X4., 

 30UrSA«T0«. 



THE TRAXSyB^.'Og MfCOTDC ?90H gOKE IWO gX>00 USINC A 



^ . pgffcap CAKivE owe 



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a^:^*SY A.VD cowcmsiOHS ^ ,- 



^Uowlnc discussions wlthla T>R<C. with Dr. K Kand on the pKanucologlski 

 r«40tlon i^ nicotine, It was agreed to collaborate with lUnd and Clark In a 

 terlet of ex^^aents at the School of Pharaaejr. University of London. These 

 prellBlnArr expeHiMnts with a pcrfuaed e^Mne lun( we^ f ls«d «t deterolnlns 

 the rate of ti»0#^r^^ olootlA* fro« clsaretts SMke Into^Ui^e ^9«|| atreaa. 



The work Is tiwoapl^. due to Dr. Rand's accept anee of the^^halr of Pharatcolog^r 

 •t the University of M«lbourK(£;«ad the results aust be regarded as tenuttv* tisct 

 it was not possible to um *ft ^D^atlcAl sooklns engine. Meverthelesa the 

 following obsenratlona were ma«* '(Q ^ 



1. Nicotine Is transferred wj raW^ly froa cigarette aawke to the blood 

 streaa. The nicotine concentration )C» the blood reached a Baxl«ua 

 concentration 1-2 alnutes after the flrtfjHffi this tlM was very 

 slallar to that fovnd for nicotine lajeeted iA^o the blood streaa 

 (1-1.5 ■Inutea). Oy^ 



o 



2. Ko Beasurable difference was detected in the Mte of'-'^sorptlon of 



OB 



nicotine fro* smoke having different ratios of extractabQ nicotine. f 



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A larger percentage of the nicotine was absorbed fro« ftlgare^ aaokc ji_ 

 which had a high proportion of extractable nicotine than frc« saoke • 



