328 



l(cs«*r<h * 0*vtlo(wnt bUbUshaant, 

 Eritlt.'fAMrl««a Toteeeo Co. U4., 

 SO^/nAMJTOM. 



DC/CAV»«« •. a6u» JUrch, 1970. 



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^^■^, (ft«P»rt Mo. RB.701-.'^) 





S'->y>RY 



A irl«l hia been completed -o lavkstlgat* the rel»tlon be*.-ec- pr>>Tl9- 

 loii^l effect »r.d nicotine delivery. Tt'jl ph/«lelojle»l par»n«',<r» wert 



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tof>H durlx^ and UcedUtcly &rter srekugxight ^pet of el;arettt 

 by a pttnel ^ hLiAAn volunteers. Ihe results shoi^thAt tho aettureae.nt cf 

 heart r«t* c^>u^ appeu-ed the aost r«ll4blt of the 'fiructar* and t^ie 

 group Averafi rcsulT^ showed a.t Lr.dlcatlon of * relation- wtwew totAl 

 nleotLne delivery and fairSrease Ln heart rate during the smoking period. 

 The changes In sJcLn raslstaqr^ and ckLn teoperature were less erratic 

 than previously, but sttll dld'o&t a^-o« a relation irlth nicotine delivery 

 or Impact on Inhaling. v'. 



The experience gained durlnc Usls owl the previous trial has 

 allowed the Identification of probable sourMS of error and varlane*. 

 Hecomciendatlons are aade to Irprovc the InstruatevtAtlon. cj^perlacntal 



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technique and envlronaental conditions. ''^^ 



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